前立腺肥大イヌの下腹神経刺激尿道内圧上昇に対するシロドシン(KMD-3213)の作用(<特集>シロドシン)

概要

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We compared the urethral and cardiovascular effects of silodosin (selective α_<1A>-adrenoceptor antagonist), a novel medication for benign prostatic hyperplasia (BPH), with those of tamsulosin (selective α_<1A>/α_<1D>-adrenoceptor antagonist) and naftopidil (selective α_<1D>-adrenoceptor antagonist). We evaluated the effects of these three drugs on the increase in intraurethral pressure (IUP) induced by electrical stimulation of the hypogastric nerve in anesthetized dogs with spontaneous BPH. All three drugs dose-dependently reduced both the increase in IUP and the mean blood pressure (MBP). The rank order of potencies was tamsulosin>silodosin>naftopidil for the reductions in both IUP and MBP. However, the uroselectivity (ED_<15> value for hypotensive effect/ID_<50> value for reduction in IUP) of silodosin (uroselectivity, 19.8) was about 21 and 4 times higher than that of tamsulosin (0.939) and naftopidil (4.94), respectively. These data suggest that silodosin might be one of the most useful medications for dysuria in BPH patients.
2006-03-01