Effect of Congestive Heart Failure on Mexiletine Pharmacokinetics in a Japanese Population(Biopharmacy)
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概要
- 論文の詳細を見る
Objective: The goal of this study was to evaluate the influence of congestive heart failure (CHF) on the clearance of mexiletine. Methods: The mexiletine clearance/bioavailability (CL/F) ratio was estimated in 584 inpatients receiving mexiletine therapy. The study population consisted of 210 patients with CHF [CHF group; 116 inpatients with New York Heart Association (NYHA) class I-II (group NYHA I-II) CHF and 94 inpatients with NYHA class III-IV (group NYHA III-IV) CHF] and 374 inpatients without CHF (Non-CHF group). Serum levels of mexiletine were determined by high performance liquid chromatography (HPLC). Results: Mexiletine clearance was significantly lower in the CHF group when compared with the Non-CHF group (0.264±0.093 vs. 0.393±0.082l/h/kg, mean±S.D., p<0.05). Further, the CL/F ratio was 50% lower in group NYHA III-IV when compared with the Non-CHF group, and the CL/F ratio tended to change in inverse proportion to NYHA class. Conclusion: CHF status significantly affects mexiletine clearance. Therefore, dose adjustments and careful monitoring are likely required in CHF patients receiving mexiletine.
- 公益社団法人日本薬学会の論文
- 2006-11-01
著者
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UENO Kazuyuki
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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Ueno K
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Ueno Kazuyuki
国立医薬品食品衛生研究所 薬物応答予測プロジェクト
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Ueno Kazuyuki
新潟薬科大学 薬剤学
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FUKUMOTO Kyoko
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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KOBAYASHI Mariko
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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Kobayashi Mariko
Department Of Cardiovascular Surgery Sakakibara Heart Institute Japan Research Promotion Society For
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Ueno Kazuyuki
Department Of Aeronautical Engineering Kyoto University.
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Fukumoto Kyoko
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Urashima Kazuya
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Kobayashi Mariko
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Kobayashi Mariko
Department Of Cardiovascular Surgery Sakakibara Heart Institute
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KOBAYASHI Mariko
Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic
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