Relationship between Serum Aprindine Concentration and Neurologic Side Effects in Japanese(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to evaluate the relationship between the neurologic side effects associated with serum aprindine concentrations and the safety range of aprindine for the prevention of neurologic side effects in 142 Japanese inpatients. Serum aprindine concentrations were determined by high-performance liquid chromatography. A poor positive correlation was observed between dose and serum aprindine concentration (r^2=0.0419,p=0.0114), and between age and ratio of serum aprindine concentration to the dose per body weight of aprindine (r^2=0.0159, p=0.121). When aprindine concentration was <1μg/ml, almost no patients showed neurologic side effects associated with aprindine. On the other hand, about 50% of the patients showed neurologic side effects when aprindine concentrations were >1μg/ml. Here, the side effects associated with aprindine such as dizziness or intention tremors were observed in 15 patients, which later disappeared after discontinuance of aprindine therapy or a decrease in the dose. In conclusion, serum aprindine concentration should be maintained under approximately 1μg/ml in Japanese patients to prevent neurologic side effects.
- 社団法人日本薬学会の論文
- 2009-04-01
著者
-
UENO Kazuyuki
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
Ueno K
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
Ueno Kazuyuki
国立医薬品食品衛生研究所 薬物応答予測プロジェクト
-
Ueno Kazuyuki
新潟薬科大学 薬剤学
-
TSUCHISHITA Yoshimasa
Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliat
-
FUKUMOTO Kyoko
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
KUSUMOTO Masaaki
Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliat
-
Tsuchishita Yoshimasa
Department Of Pharmacy Maizuru Kyosai Hospital Federation Of National Public Services And Affiliated
-
Tsuchishita Yoshimasa
舞鶴共済病院 薬剤部
-
Kusumoto Masaaki
Department Of Pharmacy Maizuru Kyosai Hospital Federation Of National Public Services And Affiliated
-
Ueno Kazuyuki
Department Of Aeronautical Engineering Kyoto University.
-
Fukumoto Kyoko
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
Urashima Kazuya
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
Kusumoto Masaaki
Department Of Pharmacy Maizuru Kyosai Hospital Federation Of National Pubic Services And Affiliated
関連論文
- Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
- Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
- Three Novel Single Nucleotide Polymorphisms in UGT1A9
- Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
- Eleven Novel Single Nucleotide Polymorphisms in the NR1I2 (PXR) Gene, Four of which Induce Non-synonymous Amino Acid Alterations
- Relationship between Serum Aprindine Concentration and Neurologic Side Effects in Japanese(Pharmacology)
- Effects of Serum Concentrations of Disopyramide and Its Metabolite Mono-N-dealkyldisopyramide on the Anticholinergic Side Effects Associated with Disopyramide(Pharmacology)
- The Effect of Bucolome, a CYP2C9 Inhibitor, on the Pharmacokinetics of Losartan
- Effect of Amiodarone on the Serum Concentration/Dose Ratio of Metoprolol in Patients with Cardiac Arrhythmia
- Sequence-based Analysis of the CYP2D6^*36-CYP2D6^*10 Tandem-type Arrangement, a Major CYP2D6^*10 Haplotype in the Japanese Population
- Prediction of Cibenzoline Dose from that of Digoxin
- Stereoselective Effect of Amiodarone on the Pharmacokinetics of Racemic Carvedilol
- Pharmacokinetic Characteristics of Amiodarone in Long-Term Oral Therapy in Japanese Population(Biopharmacy)
- ピルジカイニドの薬物動態に及ぼす蛋白結合の影響 : 臨床データの再構築研究から
- Novel Nonsynonymous Single Nucleotide Polymorphisms in the CYP2D6 Gene
- Seven Novel Single Nucleotide Polymorphisms in the Human SLC22A1 Gene Encoding Organic Cation Transporter 1 (OCT1)
- Fourteen Novel Single Nucleotide Polymorphisms in the SLC22A2 Gene Encoding Human Organic Cation Transporter (OCT2)
- Twelve Novel Single Nucleotide Polymorphisms in ABCB1/MDR1 among Japanese Patients with Ventricular Tachycardia who were Administered Amiodarone
- Five Novel Single Nucleotide Polymorphisms in the CYP2C8 Gene, One of which Induces a Frame-shift
- Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6^*2 and/or CYP2D6^*10 alleles
- Effect of NaClO Treatment on Bonding to Root Canal Dentin Using a New Evaluation Method
- Numerical Simulation of Molten Metal Flow Produced by Induction MHD Pump Using Rotating Twisted Magnetic Field(Advanced Fusion of Functional Fluids Engineering)
- Effect of Congestive Heart Failure on Mexiletine Pharmacokinetics in a Japanese Population(Biopharmacy)
- Effect of Magnetic Field on Solidification in Cu-Pb Monotectic Alloys
- Stereoselective Metabolism of Racemic Carvedilol by UGT1A1 and UGT2B7, and Effects of Mutation of these Enzymes on Glucuronidation Activity(Biopharmacy)
- Evaluation of Factors to Decrease Bioavailability of Cyclosporin A in Rats with Gentamicin-Induced Acute Renal Failure (Biopharmacy)
- Effect of Indinavir on the Intestinal Exsorption of Amprenavir, Saquinavir and Nelfinavir after Intravenous Administration in Rats
- Fluorescence Detection of DNA Using a Novel Peroxidase Substrate, 4-(4-Hydroxyphenylcarbamoyl)butanoic Acid
- A Novel Method for Determining Peroxidase Activities Using ρ-Acetamidophenol Analogs
- A Combined Assay of Cell Vability and in Vitro Cytotoxicity with a Highly Water-Soluble Tetrazolium Salt, Neutral Red and Crystal Violet
- Benzothiazole-Containing Tetrazolium Salts That Produce Water-Soluble Formazan Dyes Absorbing at a Long Wavelength upon NADH Reduction
- 2-(5-Hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum
- 2-(5-Hydrazinocarbonyl-2-furyl)-5, 6-dimethoxybenzothiazole as a Precolumn Fluorescence Derivatization Reagent for Carboxylic Acids in High-Performance Liquid Chromatography and Its Application to the Assay of Fatty Acids in Human Serum
- Polulation Pharmacokinetic Analysis of Mexiletine in Adult Arrhythmic Patients in Japanese Population
- Lack of Interaction Between Cefdinir and Calcium Polycarbophil : In vitro and In vivo Studies
- Computation of a Rising Bubble in an Enclosure Filled with Liquid Metal under Vertical Magnetic Fields
- Visual System Experiment of MHD Pump Using Rotating Twisted Magnetic Field Applicable to High-temperature Molten Metals
- Flow Visualization of Sonic Jets Exhausting Counter to a Supersonic Free Stream Using Laser Induced Fluorescence Method
- 複雑性尿路感染症の既往のある小児に対するセフジニルの予防内服についての検討
- Pharmacokinetics of Ceftriaxione, a Third-Generation Cephalosporin, in Pediatric Patients
- Repetitive Evaluation of Fibrillation Cycle Length Predicts the Efficacy of Bepridil for Interruption of Long-Lasting Persistent Atrial Fibrillation