Polulation Pharmacokinetic Analysis of Mexiletine in Adult Arrhythmic Patients in Japanese Population
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概要
- 論文の詳細を見る
We analyzed mexiletine in Japanese patients using populaiton pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to be an influential factor on clearance. The final pharmacokinetic parameters are, CL/F=0.580-0.00369・AGE (l/h/kg) and V_d/F=6.63 (L/kg). These results shoulds be useful for adjusting the dosage to a patient's age for the prevention of an adverse reaction caused by overexposure.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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UENO Kazuyuki
Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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Ueno K
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Ueno Kazuyuki
国立医薬品食品衛生研究所 薬物応答予測プロジェクト
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Ueno Kazuyuki
新潟薬科大学 薬剤学
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SHIBAKAWA Masahiko
Department of Pharmacy, National Cardiovascular Center
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Koue T
Pharmacokinetic Section. Otsuka Assay Laboratory Otsuka Pharmaceutical Co. Ltd.
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Ueno Kazuyuki
Department Of Aeronautical Engineering Kyoto University.
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Iwai T
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.
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UENAKA Kazunori
Pharmacokinetic Section. Otsuka Assay Laboratory, Otsuka Pharmaceutical Co., Ltd.
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KOUE Toshiko
Pharmacokinetic Section. Otsuka Assay Laboratory, Otsuka Pharmaceutical Co., Ltd.
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IWAI Tetsushi
Pharmacokinetic Section. Otsuka Assay Laboratory, Otsuka Pharmaceutical Co., Ltd.
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Urashima Kazuya
Department Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Shibakawa Masahiko
Department Of Pharmacy National Cardiovascular Center
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Uenaka Kazunori
Pharmacokinetic Section. Otsuka Assay Laboratory Otsuka Pharmaceutical Co. Ltd.
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