Asymmetric Synthesis of Methyl (-)-13-Oxo-15,16-dinorlabda-8(17),11E-dien-19-oate, Methyl Ester of a Potent Suppressor toward Carcinogenic Promotor

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概要

• 論文の詳細を見る

• Asymmetric synthesis of methyl ester (4) of (-)-13-oxo-15, 16-dinorlabda-8(17), 11E-dien-19-oic acid (1), which exhibited the most potent activity for the prevention of incipient carcinogenesis among the isolated diterpenes from Thuja standishii and its related plants, was achieved by using methyl (-)-1, 4a-dimethyl-5-oxodecahy-dronaphthalene-1-carboxylate (5) as a strating material, which was easily prepared on gram scale by baker's yeast-catalyzed asymmetric reduction.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• Katoh Takahiro

  Department of Cardiology, Edogawa Hospital

• Katoh Takahiro

  Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U

• 梶本 哲也

  京都薬大

• KAJIMOTO Tetsuya

  Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University

• NODE Manabu

  Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University

• Node Manabu

  Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U

• Node M

  Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U

• Node Manabu

  Kyoto Pharmaceutical Univ.

• Node Manabu

  Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University

• Katoh Takahiro

  Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University

• MIZUMOTO Shinsuke

  Department of Pharmaceutical Manufacturing Chemistry, 21st Century COE Program, Kyoto Pharmaceutical

• FUDESAKA Masato

  Department of Pharmaceutical Manufacturing Chemistry, 21st Century COE Program, Kyoto Pharmaceutical

• Fudesaka Masato

  Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U

• Mizumoto Shinsuke

  Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U

• Kajimoto Tetsuya

  Department Of Biotechnology Tokyo University Of Agriculture And Technology

• Kajimoto Tetsuya

  Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University

• Kato Takahiro

  Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University

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