Synthesis of (-)-Epibatidine and Its Derivatives from Chiral Allene-1,3-dicarboxylate Esters
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概要
- 論文の詳細を見る
(-)-Epibatidine, an excellent candidate of non-opioidal anesthesia, was formally synthesized in short steps from di-(l)-menthyl (R)-allene-1,3-dicarboxylate that was facilely prepared as a single isomer by means of crystallization-induced asymmetric transformation from a diastereomer mixture of (R)- and (S)-allene-1,3-dicarboxylates. Taking advantage of the chiral synthesis, derivatives of (-)-epibatidine were also prepared for targeting diagnostic agents that could bind nicotinic acetylcholine receptors (nAChRs) in the mammalian central nerve system.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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Kimura Hiroyuki
Departments Of Internal Medicine School Of Medicine Keio University
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Kimura Hiroyuki
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Katoh Takahiro
Department of Cardiology, Edogawa Hospital
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FUJIWARA TOSHIO
Department of First Surgery, Dokkyo University School of Medicine
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Katoh Takahiro
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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梶本 哲也
京都薬大
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KAJIMOTO Tetsuya
Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University
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NODE Manabu
Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University
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Kimura Hiroyuki
Pharmaceutical Res. Div. Takeda Pharmaceutical Co. Ltd.
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Node Manabu
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Node M
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Node Manabu
Kyoto Pharmaceutical Univ.
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Node Manabu
Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University
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NISHIDE Kiyoharu
Department of Pharmaceutical Manufacturing Chemistry, 21st Century COE Program, Kyoto Pharmaceutical
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Katoh Takahiro
Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University
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Kajimoto Tetsuya
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Kimura Hiroyuki
Department Of Internal Medicine School Of Medicine Keio University
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Fujiwara Toshio
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Fujiwara Toshio
Department Of First Surgery Dokkyo University School Of Medicine
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Kajimoto Tetsuya
Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University
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Nishide Kiyoharu
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Nishide K
Kyoto Pharmaceutical University
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Node Manabu
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Kimura Hiroyuki
Department Of Cardiology Toyohashi Heart Center
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Kato Takahiro
Department Of Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University
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Kimura Hiroyuki
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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Nishide Kiyoharu
Department Of Pharmaceutical Manufacturing Chemistry 21st Century Coe Program Kyoto Pharmaceutical U
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