Study on Wear Reduction Mechanisms of Artificial Cartilage by Synergistic Protein Boundary Film Formation(<Special Issue>Bioengineering)
スポンサーリンク
概要
- 論文の詳細を見る
Poly(vinyl alcohol) (PVA) hydrogel is one of the anticipated materials for artificial cartilage. PVA hydrogel has high water content and a low elastic modulus similar to natural cartilage, but its major disadvantage is its lower strength. PVA hydrogel experienced rapid wear under severe conditions such as mixed or boundary lubrication. Therefore, the existence of a protective surface film with low friction becomes important to prevent surface failure. In this study, the reciprocating frictional tests for a sliding pair of PVA hydrogel and glass plate were carried out, and fluorescent observations were performed to identify the roles of adsorbed protein film. Albumin and γ-globulin, which are contained in natural synovial fluid, were used by mixing into the lubricant. It appears that groups of albumin molecules adsorb on the smooth γ-globulin adsorbed layer at content of 2.1 wt% of proteins with an appropriate ratio. But in the case of a lubricant which has excessive protein at 2.8 wt%, albumin and γ-globulin adsorbed separately. Considering the wear reduction at 2.1 wt% content of protein, albumin and γ-globulin constituted synergistic adsorbed film for wear reduction. It is indicated that albumin constructs a low shear layer and γ-globulin forms a layer protecting PVA hydrogel from wear. It is considered that wear and friction of PVA hydrogel were reduced due to slip of the boundary of adsorbed albumin and γ-globulin layer. Content of protein and ratio of albumin to γ-globulin (AG ratio) are important to constitute the appropriate protein film.
- 一般社団法人日本機械学会の論文
- 2005-12-15
著者
-
Murakami Teruo
Department Of Intelligent Machinery And Systems Faculty Of Engineering Kyushu University
-
Sawae Yoshinori
Department Of Intelligent Machinery And Systems Faculty Of Engineering Kyushu University
-
中嶋 和弘
九州大学 大学院工学研究院 機械工学部門
-
Nakashima Kazuhiro
Department Of Intelligent Machinery And Systems Faculty Of Engineering Kyushu University
-
Nakashima Kazuhiro
Department of Applied Science for Electronics and Materials, Kyushu University, Kasuga, Fukuoka 816-8580, Japan
関連論文
- Interaction of Endogenous Compounds in Human and Rat Urine with P-glycoprotein
- プロスタグランジンE_1の腎刷子縁膜輸送系は膜電位感受性であるが, パラアミノ馬尿酸輸送系とは異なる可能性がある
- Effect of Neonatal Exposure of 17β-Estradiol and Tamoxifen on Hepatic CYP3A Activity at Developmental Periods in Rats
- 水素雰囲気における無充てんPTFEの摩耗特性
- 0302 関節軟骨の潤滑特性に及ぼす軟骨下部組織の影響(OS11:軟骨の形態と機能)
- 軟骨細胞-アガロース複合体の力学的特性に対する培養条件の影響(第2報)(G02-2 細胞,G02 バイオエンジニアリング部門)
- 224 軟骨細胞-アガロース複合体の力学的特性に対する培養条件の影響
- THE DEVELOPMENT OF SHOULDER MOTOR ORTHOSIS FOR STROKE REHABILITATION(3B2 Orthopaedic & Rehabilitation Biomechanics VI)
- A POSSIBLE MECHANISM OF ABSORPTION PROMOTERS
- 生体関節液成分が人工軟骨候補材料の摩擦挙動および境界潤滑膜形成能に及ぼす影響
- 0931 人工軟骨候補材料の摩擦に与える蛋白質二次構造の影響(OS20-1:人工関節とバイオエンジニアリング1)
- J0401-5-3 関節軟骨下骨厚さが関節軟骨の摩擦挙動に及ぼす影響(生体材料およびその表面改質材(5))
- B104 人工軟骨の生体内評価
- SURFACE ANALYSIS OF THE TRIBOLOGICAL PAIR Al_2O_3 NANOCOMPOSITES AND Al_2O_3 IN DIFFERENT MEDIA(3C2 Bone & Ligament I)
- 人工軟骨用 polyvinyl alcohol ハイドロゲルの生体内固定法と安定性の評価
- A202 人工軟骨としてのPoly(vinyl-alcohol)ハイドロゲルのin vivo評価(A2-1 人工関節)
- 854 人工軟骨候補材料の低摩擦化に寄与する最適境界潤滑膜形成に及ぼすリン脂質添加の影響(G02-4 バイオエンジニアリング(4),21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)
- Tribological Characteristics of Al2O3 Nanocomposites for Joint Prostheses
- A206 蛋白質吸着膜をもつ摺動面とPoly(vinyl-alcohol)ハイドロゲルの摩擦特性(A2-1 人工関節)
- 人工軟骨材料の摩擦に対する関節液成分を含む表面膜の影響(G02-3 軟骨,G02 バイオエンジニアリング部門)
- 超高分子量ポリエチレン上の蛋白質境界潤滑膜の摩擦特性
- リン脂質二分子膜が人工軟骨候補材料の摩擦挙動に与える影響
- F24 膝関節シミュレータ試験による人工軟骨の摩擦摩耗特性の評価(F2 バイオエンジニアリング2)
- Quantitative analysis of three-dimensional complexity and connectivity changes in trabecular microarchitecture in relation to aging, menopause, and inflammation
- J0204-2-3 ヒアルロン酸・蛋白質複合吸着膜を有するハイブリッド型人工軟骨の摩擦特性([J0204-2]バイオトライボロジー(2))
- Micro-Biomechanics of Material Transport and Structuration in Mechanically Loaded Biological Tissue
- Photovoltaic properties of n-type β-FeSi2/p-type Si heterojunctions
- 1225 ヒアルロン酸溶液中における軟質材の始動摩擦特性
- S1105-2-3 PTFEの摩擦・摩耗に及ぼす水素雰囲気の影響([S1105-2]トライボロジーの基礎と応用(2))
- Influences of Newly Formed Woven Bone on Tissue Stresses in Rat Caudal Vertebrae Subjected to Mechanical Loading : A Study Based on Morphological Measurement Using a Micro-CT and Computational Stress Analysis
- Alteration of Mechanical Properties of Remodeling Bone Adapted to Mechanical Stimuli
- The Morphological Measurements with a Micro CT and the Stress Analyses of the Adaptive Remodeling by Applied Mechanical Stimuli in Rat Caudal Vertebrae
- J0204-1-2 生体関節軟骨の摩擦特性に及ぼす変形挙動の影響([J0204-1]バイオトライボロジー(1))
- J0204-1-1 蛋白質吸着膜の摩擦に与える二次構造の影響([J0204-1]バイオトライボロジー(1))
- Bioengineering Research on Frontier Technologies with Nano-, Micro- and Macro-scopic Multiple Viewpoints
- Bioengineering Research on Frontier Technologies with Nano-,Micro- and Macro-scopic Multiple Viewpoints
- 238 人工膝関節用 UHMWPE における塑性流動現象の考察
- 223 人工膝関節の脛骨金属ベースのネジ穴が UHMWPE の摩耗に及ぼす影響
- 1022 生体関節液成分から成る境界膜の形成のその場観察を通した人工軟骨候補材料の摩擦低減メカニズムの考察(G02-2 バイオエンジニアリング(2),G02 バイオエンジニアリング)
- A201 人工軟骨候補材料の摩擦面に対する蛋白質吸着挙動のその場観察(A2-1 バイオトライボロジー・人工関節)
- 8B-14 関節液中のリン脂質成分が人工軟骨候補材料の摩擦・摩耗挙動に与える影響(OS-2(1) 人工関節のバイオエンジニアリング(2))
- ROLES OF ADSORBED FILM IN HYDRATION LUBRICATION FOR ARTICULAR CARTILAGE(1A1 Micro & Nano Biomechanics I)
- 551 アルブミン及びγグロブリンの立体構造が摩擦へ与える影響(S09-4 関節のバイオメカニズム(4),S09 関節のバイオメカニズム)
- Study on Wear Reduction Mechanisms of Artificial Cartilage by Synergistic Protein Boundary Film Formation(Bioengineering)
- Influence of Proteoglycan on Time-Dependent Mechanical Behaviors of Articular Cartilage under Constant Total Compressive Deformation(Bioengineering)
- Protective Mechanism of Articular Cartilage to Severe Loading : Roles of Lubricants, Cartilage Surface Layer, Extracellular Matrix and Chondrocyte
- Finite Element Analyses for Time-dependent and Depth-dependent Deformation of Articular Cartilage and Chondrocytes Under Constant Compression
- Influence of Initial Cell Density on Mechanical Property of Cultured Chondrocytes-Agarose Construct(Micro- and Nano-biomechanics)
- 人工軟骨候補材の摩耗に及ぼす蛋白質吸着膜の影響(第2報)
- 人工軟骨候補材料ポリビニルアルコールハイドロゲルの摩耗評価及び耐摩耗性向上に寄与する蛋白質の影響(機械要素,潤滑,工作,生産管理など)
- 蛍光染色による人工軟骨摩擦面表面の吸着蛋白質の観察(G02-3 軟骨,G02 バイオエンジニアリング部門)
- Micro- and Nano-scopic Biomechanics of Articular Cartilage Focusing Chondrocytes and Surrounding Tissue
- Effect of Protein Boundary Film on Wear Reduction of Artificial Cartilage(Orthopaedic Biomechanics)
- 503 ガラス表面に吸着した蛋白質境界膜の摩耗保護効果に関する考察
- 人工軟骨候補材料の摩耗に及ぼす蛋白質吸着膜の影響
- 636 人工軟骨候補材の摩耗に及ぼす生体関節液に含まれる蛋白質の影響
- 人工軟骨としてのPVAハイドロゲルの摩擦摩耗に及ぼす蛋白成分の影響
- 1224 生体軟骨に埋入した人工軟骨材の摩擦摩耗評価
- Substrate Temperature Dependence of Photovoltaic Properties of $\beta$-FeSi2/Si Heterojunctions Prepared by Facing-Target DC Sputtering
- Low-Temperature Annealing of n-Type $\beta$-FeSi2/p-Type Si Heterojunctions
- Electrical and Photovoltaic Properties of n-Type Nanocrystalline-FeSi2/p-Type Si Heterojunctions Prepared by Facing-Targets Direct-Current Sputtering at Room Temperature
- E21 生体軟骨および人工軟骨候補材料の変形挙動と摩擦特性の関連(E2 生体・医療福祉)
- 8A22 水素含有,水素フリーDLC膜の摩擦特性評価および蛋白質境界膜形成の可視化観察(OS03 関節のバイオニクス1)
- 7E22 人工関節材料表面上の蛋白質吸着膜の凝着力測定(GS09 バイオマテリアル)