Influence of Proteoglycan on Time-Dependent Mechanical Behaviors of Articular Cartilage under Constant Total Compressive Deformation(<Special Issue>Bioengineering)

スポンサーリンク

概要

• 論文の詳細を見る

• Articular cartilage has biphasic property based on high water content. It is generally believed that the proteoglycan supports the compressive load, but the detailed loading mechanism has not yet been clarified. In this study, first we observed the changes in compressive stress and strain of articular cartilage under constant total compressive deflection. We evaluated the changes in modulus of elasticity, which was estimated from the stress-strain relation in equilibrium state. To examine the role of proteoglycan in compressed articular cartilage, we compared the time-dependent viscoelastic behaviors in both the intact cartilage and the cartilage treated with chondoroitinase ABC under constant total compressive deformation. We could confirm that the peak stress after compression and the modulus of elasticity at equilibrium were reduced after the digestion of proteoglycan. Next, we observed the changes in local strain in both articular cartilage specimens with and without chondroitinase treatment by monitoring the position of stained chondrocyte in the con focal laser scanning microscope. These visualized images indicated that the local strain changed time-dependently and depthdependently. The digested cartilage showed the quicker change in movement and larger thinning in surface layer than the intact cartilage. These results indicate that the proteoglycan contributes to the compressive load-carrying capacity and controls the permeability.

• 一般社団法人日本機械学会の論文
• 2004-12-15

著者

• Murakami Teruo

  Department Of Intelligent Machinery And Systems Faculty Of Engineering Kyushu University

• Sakai Nobuo

  Department of Intelligent Machinery and Systems, Kyushu University

• Sawae Yoshinori

  Department Of Intelligent Machinery And Systems Faculty Of Engineering Kyushu University

• Tanaka Koji

  Previously Department Of Intelligent Machinery And Systems Graduate School Of Engineering Kyushu Uni

• Ihara Maki

  Medical Engineering Faculty Of Medical Sciences Kyushu University

• IHARA Maki

  Previously Medical Engineering, Faculty of Medical Sciences, Kyushu University

関連論文

• Interaction of Endogenous Compounds in Human and Rat Urine with P-glycoprotein
• プロスタグランジンE_1の腎刷子縁膜輸送系は膜電位感受性であるが, パラアミノ馬尿酸輸送系とは異なる可能性がある
• Effect of Neonatal Exposure of 17β-Estradiol and Tamoxifen on Hepatic CYP3A Activity at Developmental Periods in Rats
• THE DEVELOPMENT OF SHOULDER MOTOR ORTHOSIS FOR STROKE REHABILITATION(3B2 Orthopaedic & Rehabilitation Biomechanics VI)
• A POSSIBLE MECHANISM OF ABSORPTION PROMOTERS
• SURFACE ANALYSIS OF THE TRIBOLOGICAL PAIR Al_2O_3 NANOCOMPOSITES AND Al_2O_3 IN DIFFERENT MEDIA(3C2 Bone & Ligament I)
• Tribological Characteristics of Al2O3 Nanocomposites for Joint Prostheses
• The Combination Bracket System and Orthodontic Technique in Japan
• Quantitative analysis of three-dimensional complexity and connectivity changes in trabecular microarchitecture in relation to aging, menopause, and inflammation
• Micro-Biomechanics of Material Transport and Structuration in Mechanically Loaded Biological Tissue
• Influences of Newly Formed Woven Bone on Tissue Stresses in Rat Caudal Vertebrae Subjected to Mechanical Loading : A Study Based on Morphological Measurement Using a Micro-CT and Computational Stress Analysis
• Alteration of Mechanical Properties of Remodeling Bone Adapted to Mechanical Stimuli
• The Morphological Measurements with a Micro CT and the Stress Analyses of the Adaptive Remodeling by Applied Mechanical Stimuli in Rat Caudal Vertebrae
• Bioengineering Research on Frontier Technologies with Nano-, Micro- and Macro-scopic Multiple Viewpoints
• Bioengineering Research on Frontier Technologies with Nano-,Micro- and Macro-scopic Multiple Viewpoints
• ROLES OF ADSORBED FILM IN HYDRATION LUBRICATION FOR ARTICULAR CARTILAGE(1A1 Micro & Nano Biomechanics I)
• Study on Wear Reduction Mechanisms of Artificial Cartilage by Synergistic Protein Boundary Film Formation(Bioengineering)
• Influence of Proteoglycan on Time-Dependent Mechanical Behaviors of Articular Cartilage under Constant Total Compressive Deformation(Bioengineering)
• Time-dependent and Depth-dependent Deformation of Biphasic Articular Cartilage under Constant Total Compressive Deflection(Micro- and Nano-biomechanics)
• Protective Mechanism of Articular Cartilage to Severe Loading : Roles of Lubricants, Cartilage Surface Layer, Extracellular Matrix and Chondrocyte
• Finite Element Analyses for Time-dependent and Depth-dependent Deformation of Articular Cartilage and Chondrocytes Under Constant Compression
• Micro- and Nano-scopic Biomechanics of Articular Cartilage Focusing Chondrocytes and Surrounding Tissue

もっと見る 閉じる

スポンサーリンク