Characterization and Evaluation of Silk Protein Hydrogels for Drug Delivery
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概要
- 論文の詳細を見る
The objective of this study was to characterize and evaluate the physicochemical properties and drug release profiles of hydrogels composed of silk protein (SP) polymers. SPs with a low MW (SPL, ca. 18kDa) and a high MW (SPH, ca. 76 kDa) were used for preparing hydrogels. Both the random coil form and β-sheet conformation simultaneously existed in the hydrogels according to Fourier-transformed IR determination. Morphologically, the hydrogels showed a sponge-like cross-linked structure produced by physical entanglement as well as chemical hydrogen and covalent bindings. The in vitro buprenorphine delivery from SPH hydrogels showed a slow-release effect, and a zero-order rate was obtained for all preparations. Drug release could be controlled by varying the SPH concentrations or incorporation of SPL into the systems. SP hydrogels showed a stronger barrier property for hydrophilic solutes than for hydrophobic solutes. The incorporation of SPH into Pluronic F-127 (PF-127) hydrogels changed the gel structure from amorphous micelles to a regularly interconnected texture with pores. Furthermore, SPH as an adjuvant polymer in PF-127 and chitosan hydrogels lowered and controlled the amount of drug released from those systems.
- 公益社団法人日本薬学会の論文
- 2006-02-01
著者
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Fang Jia-You
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
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Fang Jia-you
Pharmaceutics Lab. Graduate Inst. Of Natural Products Chang Gung Univ.
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Chen Jyh-ping
Graduate Institute Of Biochemical And Biomedical Engineering Chang Gung University
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Leu Yann-lii
Natural Products Lab. Graduate Inst. Of Natural Products Chang Gung Univ.
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WANG Hsin-Yuan
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
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Wang Hsin-yuan
Pharmaceutics Laboratory Graduate Institute Of Natural Products Chang Gung University
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Chen Jyh-Ping
Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University
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