Chitosan Hydrogel as a Base for Transdermal Delivery of Berberine and Its Evaluation in Rat Skin
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概要
- 論文の詳細を見る
Berberine is the main ingredient of Coptis spp. This study selected berberine as a model drug to design a transdermal delivery system for the treatment of cutaneous leishmaniasis. Berberine was incorporated into chitosan hydrogel to prepare ointments. The physicochemical properties of the ointments and the release profile of berberine were investigated. The results indicated that the viscosity of chitosan hydrogel increased with an increasing amount of lactic acid or EDTA. The effect of EDTA on the viscosity was greater than that of lactic acid. By differential scanning calorimetry (DSC) measurement, no interaction was found to occur between chitosan and the soluble berberine. The release rate of berberine was inversely proportional to ointment viscosity. In in vitro skin perfusion studies, only trace amounts of berberine permeated through the rat skin due to its low oilwater partition coefficient. Surfactants were used as penetration enhancers to increase the percutaneous absorption of berberine. Among the enhancers, benzalkonium chloride was found to be the most efficient. Additionally, Tween 80 could increase the loading amount of berberine in the skin.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Fang Jia-You
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
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Fang Jia-you
Pharmaceutics Lab. Graduate Inst. Of Natural Products Chang Gung Univ.
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Fang J‐y
Chang Gung Univ. Taoyuan Twn
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Hsu L‐r
School Of Pharmacy Chia Nan College Of Pharmacy And Science
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TSAI Chia-Jung
School of Pharmacy, Chia Nan College of Pharmacy and Science
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HSU Li-Ren
School of Pharmacy, Chia Nan College of Pharmacy and Science
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FANG Jia-You
Republic of China and Graduate Institute of Pharmaceutical Sciences, Taipei Medical College
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LIN Hung-Hong
School of Pharmacy, Chia Nan College of Pharmacy and Science
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Lin H‐h
School Of Pharmacy Chia Nan College Of Pharmacy And Science
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Hsu Li-ren
School Of Pharmacy Chia Nan College Of Pharmacy And Science
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Tsai Chia-jung
School Of Pharmacy Chia Nan College Of Pharmacy And Science
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Lin Hung-hong
School Of Pharmacy Chia Nan College Of Pharmacy And Science
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