In Vitro Effect of Penetration Enhancers on Sodium Nonivamide Acetate in Rat Skin
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概要
- 論文の詳細を見る
Sodium nonivamide acetate (SNA) is a newly synthetic analogue of capsaicin which produces no overt pungent sensation or irritation. In this present study, the effects and roles of penetration enhancers for SNA through rat skin were investigated by in vitro skin penetration experiment and differential scanning calorimeter (DSC) determination. The penetration fluxes of SNA after the incorporation of enhancers increased in the order of Polysorbate 20<sodium laurylsulfate&gne ; benzalkonium chloride. This result was consistent with that of DSC profiles which indicated the disruptive effects of surfactants on the rat stratum corneum increased in the order of Polysorbate 20<sodium laurylsulfate<benzalkonium chloride. The information gained is particularly helpful in the development of SNA transdermal drug delivery system.
- 公益社団法人日本薬学会の論文
- 1995-12-15
著者
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Tsai Yi-Hung
School of Pharmacy, Kaohsiung Medical University
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Wu Pao-Chu
School of Pharmacy, Kaohsiung Medical University
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Fang Jia-You
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
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Wu P‐c
School Of Pharmacy Kaohsiung Medical Univ.
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Tsai Y‐h
School Of Pharmacy Kaohsiung Medical Univ.
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Fang Jia-you
Pharmaceutics Lab. Graduate Inst. Of Natural Products Chang Gung Univ.
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Huang Yaw-bin
School Of Pharmacy Kaohsiung Medical University
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Wu Pao-chu
School Of Pharmacy Kaohsiung Medical University
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Tsai Yi-hung
School Of Pharmacy Kaohsiung Medical University
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Fang J‐y
Chang Gung Univ. Taoyuan Twn
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FANG Jia-You
School of Pharmacy, Kaohsiung Medical University
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Huang Yaw-Bin
School of Pharmacy, Kaohsiung Medical University
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