Delivery of Resveratrol, a Red Wine Polyphenol, from Solutions and Hydrogels via the Skin(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Resveratrol, the main active polyphenol in red wine, has been demonstrated to show benefits against skin disorders. The bioavailability of orally administered resveratrol is insufficient to permit high enough drug concentrations for systemic therapy. In this study, we examined the feasibility of the topical/transdermal delivery of resveratrol. The effects of vehicles on the in vitro permeation and skin deposition from saturated solutions such as aqueous buffers and soybean oil were investigated. The general trend for the delivery from solutions was: pH 6 buffer=pH 8 buffer>10% glycerol formal in pH 6 buffer>pH 9.9 buffer>pH 10.8 buffer>soybean oil. A linear relationship was established between the permeability coefficient (K_p) and drug accumulation in the skin reservoir. Viable epidermis/dermis served as the predominant barrier for non-ionic resveratrol permeation. On the other hand, both the stratum corneum (SC) and viable skin acted as barriers to anionic resveratrol. Several prototype hydrogel systems were also studied as resveratrol vehicles. The viscosity but not the polarity of the hydrogels controlled resveratrol permeation/deposition. Piceatannol, a derivative of resveratrol with high pharmacological activity, showed 11.6-fold lower skin permeation compared to resveratrol. The safety profiles of resveratrol suggested that the hydrogel caused no SC disruption or skin erythema. It was concluded that delivery via a skin route may be a potent way to achieve the therapeutic effects of resveratrol. This is the first report to establish the permeation profiles for topically applied resveratrol.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
-
Fang Jia-You
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
-
Fang Jia-you
Pharmaceutics Lab. Graduate Inst. Of Natural Products Chang Gung Univ.
-
Lin Yin-ku
Graduate Institute Of Clinical Medical Sciences Chang Gung University:department Of Traditional Chin
-
Fang Jia-you
Pharmaceutics Laboratory Graduate Institute Of Natural Products Chang Gung University
-
HUNG Chi-Feng
School of Medicine, Fu Jen Catholic University
-
HUANG Zih-Rou
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University
-
Huang Zih-rou
Pharmaceutics Laboratory Graduate Institute Of Natural Products Chang Gung University
-
Hung Chi-feng
School Of Medicine Fu Jen Catholic University
関連論文
- Tryptanthrin-Loaded Nanoparticles for Delivery into Cultured Human Breast Cancer Cells, MCF7: the Effects of Solid Lipid/Liquid Lipid Ratios in the Inner Core
- Transdermal Delivery of Tea Catechins and Theophylline Enhanced by Terpenes : a Mechanistic Study(Biopharmacy)
- Noninvasive Glucose Monitoring by Back Diffusion via Skin : Chemical and Physical Enhancements
- Influence of Electrical and Chemical Factors on Transdermal Iontophoretic Delivery of Three Diclofenac Salts
- Passive and Iontophoretic Delivery of Three Diclofenac Salts across Various Skin Types
- Cyclic Monoterpene Extract from Cardamom Oil as a Skin Permeation Enhancer for Indomethacin : In Vetro and in Vivo Studies
- Chitosan Hydrogel as a Base for Transdermal Delivery of Berberine and Its Evaluation in Rat Skin
- Transdermal Delivery of Sodium Nonivamide Propionate by Iontophoresis
- Characterization and Stability of Various Liposome-Encapsulated Enoxacin Formulations
- In Vitro Effect of Penetration Enhancers on Sodium Nonivamide Acetate in Rat Skin
- Delivery of Resveratrol, a Red Wine Polyphenol, from Solutions and Hydrogels via the Skin(Biopharmacy)
- Characterization and Evaluation of Silk Protein Hydrogels for Drug Delivery
- Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas
- Physicochemical Characterization and Drug Release of Thermosensitive Hydrogels Composed of a Hyaluronic Acid/Pluronic F127 Graft
- Effect of liposome encapsulation of tea catechins on their accumulation in basal cell carcinomas
- Electrically-Assisted Skin Permeation of Two Synthetic Capsaicin Derivatives, Sodium Nonivamide Acetate and Sodium Nonivamide Propionate, via Rate-Controlling Polyethylene Membranes(Biopharmacy)