炭酸カルシウム,β-リン酸三カルシウム,シロキサン含有ポリ乳酸複合中空球体の作製

概要

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Biodegradable inorganic-organic composite hollow spheres, consisting of poly (L-lactic acid) , calcium carbonate, β-tricalcium phosphate and siloxane, were prepared by an oil-in-water emulsion evaporation method to develop an injectable bone substitutes incorporated with cells. The spheres had an almost flat diameter of about 1.0mm and an open channel of 500-600μm in diameter on the shell. After soaking the spheres in a simulated body fluid, the silicon and calcium ion-species were gradually released from the spheres. Osteoblast-like cells, marrow stromal cells (MSCs) and osteoblasts migrated into the spheres through the open channel and attached to the inside surface of the sphere shell. The MSCs expressed a high level of alkaline phosphatase on the spheres. Some bone nodules formed on the spheres after the culture of osteoblasts.
2006-09-01