J0401-1-6 金属チタンへのコーティングを目的としたポリ乳酸系ハイブリッド材料(生体材料およびその表面改質材(1))

概要

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Some properties of poly(lactic acid)-based hybrids/composites containing siloxane and calcium carbonate (vaterite) were investigated and the possibility as bioactive coatings on metallic titanium-based materials was discussed. A novel hybrid containing polysiloxane was prepared using aminopropyltriethoxysilane (APTES). Polysiloxane partially assembled in the membrane and a molecular chain of poly(L-lactic acid) (PLLA) was bonded through the amide bond. The hybrid formed hydroxyapatite (HA) on its surface after 3 days of soaking in simulated body fluid. The HA layer included ionic silicon-species. The hybrid coated with silicon-species-containing HA showed excellent cell-proliferation ability. The existence of silicon-species in the material may have a tendency to stimulate the proliferation. Nano- or Microfiber meshes releasing a trace amount of silicon species were prepared by electrospinning siloxane-doped vaterite and PLLA hybrids (Si-PVH). The electrospun meshes have adequate flexibility and large spaces for cell-ingrowth. PLLA solution was dip-coated on a titanium plate and subsequently the sample was heated at 170℃ for 30 min: the PLLA layer of 〜10 μm-thickness was strongly adhered with the substrate. Si-PVH was successfully electrospun on the titanium coated with the PLLA layer: SiPVH fibers were bonded with the PLLA layer.
2009-09-12