炭疽沈降素血清の特異性に関する研究 : 第11報抗炭疽血清に強陽性を示す細菌間の抗原関係

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In connection with the work published in the previous report 10, experiments by the usual precipitation method were made on antigenic relation to B. anthracis of the organisms of the genus Bacillus-B. megatherium, B. pseudoanthrads, and organisms of B. 1, B. 16, B. 17, B. 18, B. 19, B. 20 and B. 21 which were isolated in our laboratory-and on mutual antigenic relation of these organisms. Comparative re-examination of both bacterial extracts and products as antigens was also carried out. A. Results obtained with bacterial extracts used as antigens. 1. The four organisms, B. megatherium, B. 1, B. 17 and B. 20, are extremely related to B. anthracis in antigenicity. They react well each other and it is difficult to separate these four antigenically from B. anthracis. It is, therefore, interesting that if ASCOLI'S precipitin test is made with antisera prepared against these four organisms and materials from anthrax-infected animals, a positive reaction like in the case of anti-anthrax serum may occur. B. anthracis, however, may be separated from the four by its weak antigenicity to any one of the antisera prepared against B. 16, B. 18, B. 21, B. pseudoanthrads, etc. 2. The three organisms, B. 16, B. 18, and B. 21, are extremely related each other in antigenicity. They exhibit antigenic properties similar to those of the four organisms described above. They are, however, differentiated from the above four by the weak reaction of their antisera with B. anthracis. 3. B. pseudoanthracis exhibits very close antigenicity to the above three organisms of B. 16, B. 18 and B. 21, and it is difficult to separate from these three. In the present work differentiation is attempted by its antigenicity to antisera prepared against the other test organisms. 4. B. 19 clearly differs in antigenicity from the other organisms and with the exception of B. 18, no organisms reacted with the antiserum of this organism. Differentiation from B. 18 is, of course, evidently capable, since antisera of both organisms exhibit each other different reactions with the other organisms. B. Results obtained with bacterial products used as antigens. 1. Antigenic difference (or similarity) between bacterial species was rather evidently exhibited with the bacterial products than with the extracts. 2. All the organisms tested are, like in the case of experiment A, classified grossly into four groups, the group of B. megatherium, B. 1, B. 17, B. 18 and B. 20, and the group of B. 16 and B. 21, and the remaining two groups of B. pseudoanthracis and B. 19. These latter two, respectively, exhibited quite specific antigenicity which differed from each other. 3. The result which differed from that of experiment A was that B. anthracis exhibited the same antigenic properties as observed with the four organisms of the B. megatherium group and even with its antigenicity to antisera prepared against the other organisms exclusive of the above four, such differentiation as that capable in the case of the bacterial extract was quite impossible. In experiment A, B. 18 rather resembled B. 16 and B. 21 and these three belonged to the same group, but experiments with products clarified that this organism is rather related to the organisms of the B. megatherium group. 4. Since the B. 17 product reacts with the antisera of both B. 16 and B. megatherium groups, this organism seems to be of the intermediate type of these two groups. From the results described above, mutual antigenic differences were recognized even between bacterial species which were almost impossible to differentiate each other by their antigenicity to anti-anthrax serum.
大阪府立大学の論文
1957-01-25

炭疽沈降素血清の特異性に関する研究 : 第11報抗炭疽血清に強陽性を示す細菌間の抗原関係

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炭疽沈降素血清の特異性に関する研究 : 第11報 抗炭疽血清に強陽性を示す細菌間の抗原関係

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炭疽沈降素血清の特異性に関する研究 : 第11報抗炭疽血清に強陽性を示す細菌間の抗原関係