ラット実験白血病培養株における癌遺伝子発現

概要

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Expression of c-Ha-ras and c-myc was observed by the Northern blot method in cultured cell lines K1DB, K1DD, K2DA, K3D and K4D established from three transplantable cell lines of DMBA-induced rat leukemia. Thus, they were considered important for leukemia cell proliferation. Other oncogenes expressed included c-erbB in K1DD and c-abl in K3D while the latter was not expressed in its parent cell line K2D. No abnormality was observed in the size of mRNA of c-abl, c-Ha-ras and c-myc in these leukemia. Although c-abl was located chromosomally in the breakpoint of trans location (3 ; 12) suggesting a close relationship between the oncogene expression and the chromosomal change; no relationship was demonstrated between oncogene expression and other chromosomal changes.In conclusion, oncogene expression of chemically induced rat leukemia was successfully surveyed in the present studies.
神戸大学の論文