片側側頭葉前部切除術に伴なう高次脳機能の改善の可能性について

概要

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Purpose: This study examined whether the improvement of the contralateral temporal function and/or the frontal function would occur following unilateral anterior temporal lobectomy. Methods: Twenty-five patients who had undergone either a right (RTL, n=18) or left (LTL, n=7) unilateral anterior temporal lobectomy for treatment of medically intractable epilepsy were particiated. Each patient received the Wechsler Memory Scale-Revised (WMS-R) and the Wisconsin Card Sorting test (WCST) before and after RTL or LTL. Results: RTL patients showed that the 3 of 5 indexes of WMS-R (General Memory Index, Verbal Memory Index and Delayed Recall Index) and a number of archived categories of WCST were increased following RTL. In contrast, there were no significant increases or decreases in WMS-R and WCST before and after LTL. Conclusions: Although LTL would have no effects on the contralateral memory functions related to the right temporal lobe and the executive function of the frontal lobe, RTL could affect improvement of verbal memory related to the contralateral left temporal lobe and of the frontal executive function. This suggested that the possibility of right temporal lobectomy which released to contralateral verbal function related to the left temporal lobe and to the frontal executive function from inhibitory influence of the right temporal focus.
長崎純心大学・長崎純心大学短期大学部の論文
2004-03-01