複数皮質活動の動的イメージングのためのfMRI-MEG統合解析法

概要

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We have developed an fMRI-MEG integrative method that is capable of analyzing spatiotemporal multiple cortical activities. Firstly, activated regions were determined by statistically analyzing fMRI data. Secondly, using fMRI analysis results as a spatial constraint, the location and orientation of equivalent current dipoles (ECD) were estimated by a procedure that maximizes the inner product of lead field and measured field vectors. The time-varying dipole moment was obtained by projecting the optimized lead field vector to measured fields. We applied the technique to data obtained during a visual perception task. An apparent motion stimulus that activates both primary and secondary visual areas (V1/2) and V5 was used in the experiment. Event-related neuromagnetic fields were measured by a 306-channel MEG system, whereas the fMRI data were acquired by a 1.5 TMR system. The present fMRI-MEG integrative analysis method successfully detected dynamic cortical activities in V1/2 and V5.
社団法人日本生体医工学会の論文
2005-12-10