Comparison of In Vitro Activity of Azithromycin and Ampicillin against 31 Isolates of Streptococcus Milleri
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概要
- 論文の詳細を見る
Antibacterial action of azithromycin against 31 strains of dental infection-derived Streptococcus milleri and tissue transfer of the agent were compared with ampicillin, the drug of first choice for dental infections. Concentrations required to inhibit 50% of isolates (MIC_<50>) and Concentrations required to kill 50% of isolates (MBC_<50>) were 0.10 and 0.2μg/ml, respectively, for azithromycin. The antibacterial action of azithromycin was 4 times more potent in than ampicillin. The MBC_<90> for azithromycin was 0.39μg/ml, for amplicill 3.13μg/ml. Bactericidally, azithromycin was 8 times more active than ampicillin. The peak value of concentations (Cmax) of azithromycin was 0.45μg/ml, about 1/10 that of ampicillin. The half-life of azithromycin was 10 hours, about 5 times longer than that of ampicillin. The contact time of MIC_<90> concentrations for azithromycin was 12 hours, distinctly longer than the 8 hours calculated for ampicillin. Azithromycin showed excellent tissue transfer concentrations: the gingival transfer concentration following oral administration of 500mg/day ranged from 0.7-23.5μg/ml.
- 東海大学の論文
著者
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Sasaki Jiro
Department Of Oral Surgery Tokai University School Of Medicine
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Sasaki Jiro
Department Of Oral School Of Medicine Surgery Tokai University
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Kaneko Akihiro
Department Of Oral Surgery Tokai University School Of Medicine
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Kaneko A
Tokai Univ.
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Kaneko A
National Cancer Center Tokyo Jpn
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Kaneko Akihiro
Department Of Ophthalmology National Cancer Center
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