The Dynamics of Clindamycin-2-Phosphate in vivo and its Transfer to Tissues

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Studies were conducted on clindamycin-2-phosphate, a preparation of clindamycin CLDM developed for injection, and the following results were obtained: 1) The concentration of CLDM phosphate and lincomycin (LCM) in sera were measured in rabbits following continuous intravenous infusion of 20mg/kg over a 60 minute period, and the results were compared in a crossover test. 2) The concentration of CLDM phosphate in the oral tissues of rabbits following continuous intravenous drip infusion of 20mg/kg over a 60 minute period was found to be a maximum in the submaxillary gland (21.1μg/g), followed by the liver, submaxillary lymph nodes, sera and tongue. The concentration of LCM was found to be the highest in the submaxillary gland (20.2μg/g), followed by the submaxillary lymph nodes, tongue, sera and liver. 3) The metabolism of CLDM phosphate in vivo was investigated using TLC. CLDM phosphate was found to metabolize to CLDM N-demethyl CLDM in vivo. 4) The peak concentration of CLDM phosphate in human sera following intravenous drip infusion of 600mg over a 60 minute period averaged 11.9μg/ml, while the average concentration of LCM in sera under identical circumstances was approximately twice that of CLDM phosphate.
東海大学の論文