A Preliminary Study on the Use of Unaffected Siblings for the Marker Allele Frequency of Sib-Pair Linkage Analysis
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概要
- 論文の詳細を見る
We have searched the disease-susceptibility genes of rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage method. One unaffected sibling was typed in addition to affected sib-pairs, since most parents were not typed due to late onset nature of the disease. In order to verify appropriateness of using unaffected siblings for the calculation of marker allele frequency of the population, we have compared the calculation of marker allele frequency based on unaffected siblings of patient families with that based on unrelated healthy control. Chi-square test showed no statistically significant difference between them. It thus appears that unaffected siblings can be used for the calculation of marker allele frequency especially when unaffected siblings are selected carefully by paying attention to the penetrance of disease.
- 神戸大学の論文
- 1997-12-26
著者
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SHIOZAWA Shunichi
Kobe University School of Medicine Faculty of Health Science
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HAYASHI Sachiko
Kobe University School of Medicine Faculty of Health Science
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TSUKAMOTO Yasuo
Kobe University School of Medicine Faculty of Health Science
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GOKO Hideki
Kobe University School of Medicine Faculty of Health Science
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KAWASAKI Hiroki
Kobe University School of Medicine Faculty of Health Science
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WADA Takahiko
Kobe University School of Medicine Faculty of Health Science
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SHIMIZU Kazuhiko
Kobe University School of Medicine Faculty of Health Science
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SHIOZAWA Kazuko
Center for Rheumatic Diseases, Kakogawa National Hospital
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IMURA Shigeaki
Center for Rheumatic Diseases, Kakogawa National Hospital
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Shiozawa Shunichi
Department Of Gastroenterology And Hepatology Shimane University School Of Medicine
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Satoh Shuichi
Second Department Of Internal Medicine Shimane Medical University
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Sakai Shino
Second Department Of Internal Medicine Shimane Medical University
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Shimizu Kazuhiko
Rheumatic Diseases Center Konan Kakogawa Hospital
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Shiozawa Shunichi
Department Of Medicine And The Center For Rheumatic Diseases Kobe University Hospital
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Goko H
Dep. Hea. Sci. Fac. Med. Kobe Univ.
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Imura Shigeaki
Center For Rheumatic Diseases Kakogawa National Hospital
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Shiozawa Shunichi
Division Of Rheumatology Department Of Medicine And Biophysics Kobe University Graduate School Of Me
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