238 細胞骨格の発達方向性がせん断接着力・剥離エネルギーに及ぼす影響(OS1-13 : 生体マイクロ・ナノ新技術(2),マイクロ・ナノバイオメカニクス)

概要

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Cytoskeleton plays an important role in cell-material adhesion. Formation of stress fibers increases cell adhesive shear force. In this study, we examined effect of direction of stress fibers on cell adhesive shear force. We measured the cell adhesive shear force of three types of fibroblasts to fibronectin or albumin coated glass by changing detachment direction (O or 90 degree against the direction of stress fibers). We also observed stress fibers by immunofluorescent staining. As a result, relation between cell adhesive shear force and direction of stress fibers depends on the stress fiber formatidn which changes by the type of cell. When cell has long, developed stress fibers, cell adhesive shear'force is larger at the detachment direction 90 degree than that of O degree.
社団法人日本機械学会の論文
2005-01-21