肺移植における reimplantation response に対する superoxide dismutase(SOD) の効果に関する実験的研究

概要

論文の詳細を見る
The purpose of this study was to examine the effects of superoxide dismutase (SOD) on warm ischemic reperfusion injury and the reimplantation response in canine lung transplantation. In an acute experiment, we divided the experimental animals into 5 groups, namely, group 1 : a hilar stripping group, group 2: a warm ischemia with deflated lung group, group 3 : a warm ischemia with inflated lung group, group 4 : the group with the same procedure as group 2 and treated with SOD, and group 5 : the group with the same procedure as group 3 and treated with SOD. As a chronic experiment, autotransplantation of the left lung was performed and SOD was injected prior to reperfusion. The results were as follows: 1) The 1-hr. warm ischemia and deflated lung group showed prominent edema and the poorest lung function, while the groups given SOD showed little edema and better lung function. 2) The 1-hr. warm ischemia and inflated lung group showed better lung function than the deflated lung group even without SOD treatment. 3) Administration of SOD prior to reperfusion in lung autotransplantation was able to reduce the reimplantation response. These results suggested that the main cause of the reimplantation response after lung transplantation is warm ischemic reperfusion injury and that the administration of SOD prior to the reperfusion is effective in preventing both ischemic injury and this response.
神戸大学の論文