血管炎症候群に対するアフェレシス療法の有効性(<特集>腎・血液領域の注目すべき疾患-アフェレシス療法のエビデンスとガイドライン-)

概要

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Apheresis has been performed for the treatment of vasculitis. We reviewed the literature in relation to its efficacy. In ANCA-associated vasculitis patients who had lung hemorrhage or rapidly progressive glomerulonephritis requiring dialysis, the usefulness of plasmapheresis was demonstrated in some reports. However, the renal prognosis did not differ significantly between groups that were and were not treated by plasmapheresis in some randomized control studies. Cytapheresis was shown to be effective for the treatment of lung hemorrhage or rapidly progressive glomerulonephritis caused by MPO-ANCA-associated vasculitis in a single center retrospective study. For HBV-related polyarteritis nodosa, plasmapheresis appears to be effective in combination with antiviral agents and/or immunosuppressants. Plasmapheresis is effective in subgroups of cryoglobulinemia. A prospective study is needed to evaluate the indications for plasmapheresis.
日本アフェレシス学会の論文
2006-02-28