腎臓疾患に対する白血球系細胞吸着・除去療法 : 顕微鏡的多発血管炎による急速進行性糸球体腎炎に対する治療経験(<特集>白血球系細胞除去療法の最近の展開)

概要

論文の詳細を見る
We evaluated the efficacy of cytapheresis for the treatment of rapidly progressive glomerulonephritis (RPGN) due to microscopic polyangiitis. Five patients were treated by granulocytapheresis and another five patients were treated by leukocytapheresis. The prednisolone dose was 0.2 to 1.2mg/kg/day. Pre-treatment serum creatinine was 1.4-5.1mg/dl. Renal function improved in seven of the ten RPGN patients. None of the ten patients experienced life-threatening infection. Cytapheresis seems to be an effective and safe treatment for RPGN due to microscopic polyangiitis. To clarify the mechanism, the productivity of proinflammatory cytokines from mononuclear cells and anti-inflammatory factors in peripheral blood were examined. The productivity of proinflammatory cytokines decreased after one session of cytapheresis. Soluble tumor necrosis factor I and interleukin-10 increased after a single cytapheresis. These changes might contribute to the efficacy of cytapheresis.
日本アフェレシス学会の論文
2005-05-31