周期性好中球減少症家系にみられた早期発症型歯周炎の症例研究 : 2.発端者の姉の歯周炎の病態

概要

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Cyclic neutropenia is a rare blood disease characterized by regular 21-day cyclic fluctuations in the numbers of blood neutrophils. Periodontal diseases associated with cyclic neutropenia in members of a family manifesting cyclic neutropenia were studied to determine the roles of neutrophil function in the onset and progression of peridontal disease. The elder sister of the proband (15-yr-old female) also manifested a generalized form of early-onset periodontitis with episodes of severe periodontal destruction. However she showed better responsiveness to conventional periodontal therapy than the proband. Estimated alveolar bone loss was slower than those in the proband and the father. Peripheral blood neutrophils did not show any functional failure in phagocytosis or superoxide production. It is concluded that the absence of neutrophils might play a central role in the onset, severe progression and resistance to treatment of early-onset periodontitis with cyclic neutropenia by allowing opportunistic infection in the periodontal tissues.
福岡歯科大学学会の論文
1998-03-31