E-CELLシステムによる赤血球細胞シミュレーション(<小特集>ポストゲノムにおけるバイオシステムシミュレーション : 生命システム現象の包括的な理解に向かって)

概要

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We constructed a computer model of the human erythrocyte using E-CELL simulation system. The model has three major metabolic pathways including glycolysis, the pentose phosphate pathway, and nucleotide metabolism, as well as physical effects such as volume change along with osmotic pressure. In this article, we report two results of simulation experiments as follows : (i) Analyses of the effect of osmotic pressure that changes the cell volume. (ii) The simulation of the hereditary enzyme deficiency of glucose-6-phosphate dehydrogenase (G6PD), including the pathways for glutathione (GSH) de novo synthesis and export system of glutathione disulfide (GSSG).
日本シミュレーション学会の論文
2001-06-15