Perfluoroisobutylene-Induced Acute Lung Injury and Mortality are Heralded by Neutrophil Sequestration and Accumulation

スポンサーリンク

概要

• 論文の詳細を見る

• Perfluoroisobutylene-Induced Acute Lung Injury and Mortality are Heralded by Neutrophil Sequestration and Accumulation:Hemei WANG, et al. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences-Perfluoroisobutylene(PFIB) is a highly toxic and potentially life-threatening pneumoedematogenic agent that is usually encountered in case of fire or industrial accidents. The mechanisms by which the toxicity of PFIB are mediated remain unclear. To investigate the role of neutrophil/polymorphonuclear leukocytes(PMN) in the pathogenesis of PFIB-induced acute lung injury(ALI), mice and rats were exposed to a sublethal concentration of (130 mg/m^3 and 140 mg/m^3, respectively) for 5 min in a flow-past whole-body chamber. The general pattern for the time-course of the increase in lung PMN infiltration as measured by lung myeloperoxidase(MPO) assay was shown to be rather similar to that of the lung injury indexed by both the total protein increase in the bronchoalveolar lavage fluid(BALF) and lung wet-to-dry weight ratio, except for the earlier start and the maximal time-point of the increase in lung PMN infiltration. When neutropenia was obtained by cyclophosphamide pretreatment, death of the mice induced by an over-LCt_<50> dose of PFIB(at 190 mg/m^3 for 5min) dropped dramatically, and this was very well supported by observations in the BALF total protein analysis, histopathological as well as ultrastructural studies. These results confirmed that PFIB inhalation-induced ALI and mortality are heralded by the influx of PMNs into the lung.

• 社団法人日本産業衛生学会の論文

著者

• Wang Hailan

  Guangdong Poison Control Center

• Wang Hailan

  Hospital For Occupational Diseases Control Of Guangdong Province

• Wang Hailan

  名古屋大学 医学系研究科環境労働衛生学

• Wang Hailan

  中華人民共和国

• Wang Hailan

  Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine

• ZHANG Xigang

  307 Hospital, the China PLA, P.R.

• DING Rigao

  Beijing Institute of Pharmacology and Toxicology, the China PLA, P.R.

• RUAN Jinxiu

  Beijing Institute of Pharmacology and Toxicology, the China PLA, P.R.

• SUN Xiaohong

  Beijing Institute of Pharmacology and Toxicology, the China PLA, P.R.

• WANG Hemei

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• DING Rigao

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• RUAN Jinxiu

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• YUAN Benli

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• SUN Xiaohong

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• ZHANG Xiancheng

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• YU Shouzhong

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• QU Wensheng

  Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences

• Ruan Jinxiu

  Beijing Institute Of Pharmacology And Toxicology The China Pla P.r.

• Yuan Benli

  Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences

• Ding Rigao

  Beijing Institute Of Pharmacology And Toxicology The China Pla P.r.

• Qu Wensheng

  Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences

• Sun Xiaohong

  Beijing Institute Of Pharmacology And Toxicology The China Pla P.r.

• Zhang Xigang

  307 Hospital The China Pla P.r.

• Yu Shouzhong

  Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences

関連論文

• A Survey of Semen Indices in Insecticide Sprayers
• Trichloroethylene Causes Generalized Hypersensitivity Skin Disorders Complicated by Hepatitis
• Characterization of Liver Injury Associated with Hypersensitive Skin Reactions Induced by Trichloroethylene in the Guinea Pig Maximization Test
• Human Herpesvirus 6 Reactivation in Trichloroethylene-exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction
• Suppression of Perfluoroisobutylene Induced Acute Lung Injury by Pretreatment with Pyrrolidine Dithiocarbamate
• Perfluoroisobutylene誘発急性肺障害と死亡は, 好中球の隔離と蓄積により始まる
• Perfluoroisobutylene-Induced Acute Lung Injury and Mortality are Heralded by Neutrophil Sequestration and Accumulation
• The Relationship between New Stroke Onset and Serum Thiocyanate as an Indicator to Cigarette Smoking
• Serum Thiocyanate Concentration as an Indicator of Smoking in Relation to Deaths from Cancer
• The Prophylactic and Therapeutic Effects of Cholinolytics on Perfluoroisobutylene Inhalation Induced Acute Lung Injury
• Validation of a Self-reported Physical Activity Questionnaire for Schoolchildren
• The Validity of Sleeping Hours of Healthy Young Children as Reported by Their Parents
• A Meta-analysis of Epidemiological Studies on the Relationship between Occupational Electromagnetic Field Exposure and the Risk of Adult Leukemia
• Liquid chromatography-tandem electrospray mass spectrometry method for determination of serial chiral novel anticholinergic compounds of phencynonate in rat plasma
• Determination of penehyclidine by gas chromatographic-mass spectrometry and its application to pharmacokinetics in humans, rabbits and mice
• Liquid chromatography-tandem mass spectrometry method for determination of phencynonate in rat blood and urine
• Psychosocial Stressors in Inter-human Relationships and Health at Each Life Stage : A Review
• Adverse Health Experience in Male Workers during the Boom Economy in Japan
• Nested Case-Control Study on Associations between Lung Function, Smoking and Mortality in Japanese Population
• The Validity of Nursery Teachers' Report on the Physical Activity of Young Children

もっと見る 閉じる

スポンサーリンク