Inhibitory Effects of Houttuynia cordata Water Extracts on Anaphylactic Reaction and Mast Cell Activation(Pharmacology)
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概要
- 論文の詳細を見る
The present study was investigated the effect of Houttuynia cordata THUNB water extract (HCWE) on mast cell-mediated anaphylactic reactions. The mast cell-mediated anaphylactic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. HCWE has been used as a traditional medicine in Korea and is known to have an antioxidant and anti-cancer activities. However, its specific effect of mast cell-mediated anaphylactic reactions is still unknown. We examined whether HCWE could inhibit compound 48/80-induced systemic anaphylaxis, IgE-mediated passive cutaneous anaphylaxis (PCA), and mast cell activation. The oral administration of HCWE inhibited compound 48/80-induced systemic anaphylaxis in mice. HCWE also inhibited the local allergic reaction, PCA, activated by anti-dinitrophenyl (DNP) IgE antibody in rats. HCWE reduced the compound 48/80-induced mast cell degranulation and colchicine-induced deformation of rat peritoneal mast cells (RPMC). Moreover, HCWE dose-dependently inhibited histamine release and calcium uptake of RPMC induced by compound 48/80 or anti-DNP IgE. HCWE increased the level of intracellular cAMP and inhibited significantly the compound 48/80-induced cAMP reduction in RPMC. These results suggest that HCWE may be beneficial in the treatment of mast cell-mediated anaphylactic responses.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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KIM Hyoung
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTEC
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Lee Moo
Department Of Anatomy Chonbuk National University Medical School
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Lee Moo
韓国
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Kim Hyoung
Department Of Anatomy Chonbuk National University Medical School
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CHAI Ok
Department of Anatomy, Chonbuk National University Medical School
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HAN Eui-Hyeog
Department of Anatomy, Chonbuk National University Medical School
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SONG Chang
Department of Anatomy, Chonbuk National University Medical School
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LI Guang
Department of Anatomy, Yanbian University Medical School
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HAN Eui
Department of Anatomy, Chonbuk National University Medical School
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Chai Ok
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
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Chai Ok
Department Of Anatomy Chonbuk National University Medical School
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Han Eui
Department Of Anatomy Chonbuk National University Medical School
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Song Chang
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
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Kim Hyoung
Department Of Aeronautics And Astronautics Graduate School Of Engineering Kyushu University
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Li Guang
Department Of Anatomy Yanbian University Medical School
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Song Chang
Department Of Anatomy Chonbuk National University Medical School
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Li Guang
Department Of Anatomy And Histology And Embryology Yanbian University School Of Basic Medical Scienc
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