Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE-Mediated Mast Cell Activation(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of hot-water extract from the root bark of Morus alba (HEMA) on anaphylactic reactions. Using in vitro and in vivo experiments, we examined whether HEMA could inhibit compound 48/80-induced systemic anaphylactic shock and anti-chicken gamma globulin (CGG) IgE-mediated rat peritoneal mast cell activation. HEMA significantly inhibited systemic anaphylaxis induced by the compound 48/80 in mice. HEMA also significantly inhibited the passive cutaneous anaphylaxis activated by anti-CGG IgE. HEMA had no cytotoxicity on rat peritoneal mast cells (RPMC). Moreover, HEMA dose-dependently inhibited mast cell degranulation, histamine release and calcium uptake into RPMC induced by the compound 48/80 or anti-CGG IgE. When HEMA was added, the level of intracellular cAMP in RPMC showed a transient and significant increase (5-fold) compared with that of control cells. HEMA also inhibited significantly the compound 48/80-induced cAMP reduction in RPMC. These results suggested that HEMA inhibits the compound 48/80- or anti-CGG IgE-induced mast cell activation and its inhibitory effects on mast cell activations were favorably comparable to disodium cromoglycate. And HEMA is a candidate for effective therapeutic tools of allergic diseases.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
-
KIM Hyoung
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTEC
-
Lee Moo
Department Of Anatomy Chonbuk National University Medical School
-
Lee Moo
韓国
-
Kim Hyoung
Department Of Anatomy Chonbuk National University Medical School
-
CHAI Ok
Department of Anatomy, Chonbuk National University Medical School
-
HAN Eui-Hyeog
Department of Anatomy, Chonbuk National University Medical School
-
SONG Chang
Department of Anatomy, Chonbuk National University Medical School
-
HAN Eui
Department of Anatomy, Chonbuk National University Medical School
-
Chai Ok
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
-
Chai Ok
Department Of Anatomy Chonbuk National University Medical School
-
Han Eui
Department Of Anatomy Chonbuk National University Medical School
-
Song Chang
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
-
Kim Hyoung
Department Of Aeronautics And Astronautics Graduate School Of Engineering Kyushu University
-
Song Chang
Department Of Anatomy Chonbuk National University Medical School
関連論文
- Deformation characteristics evaluation of modified equal channel angular pressing processes (Special issue on severe plastic deformation for production of ultrafine structures and unusual mechanical properties: aiming breakthrough in materials development
- Deformation Characteristics Evaluation of Modified Equal Channel Angular Pressing Processes
- Inhibitory Effects of Agaricus blazei on Mast Cell-Mediated Anaphylaxis-Like Reactions(Pharmacology)
- Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus(Pharmacology)
- Inhibitory Effects of Houttuynia cordata Water Extracts on Anaphylactic Reaction and Mast Cell Activation(Pharmacology)
- Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE-Mediated Mast Cell Activation(Pharmacology)
- D-12-36 EMPLOYING BLURRED EDGE IMAGES FOR REDUCING DRESS EFFECTS IN HUMAN POSTURES RECOGNITION
- Influence of In-Situ Nanoprecipitation on Constant Load Deformation in the Glass Transition Region of a Cu_Zr_Ti_ Bulk Metallic Glass
- Microforming of Bulk Metallic Glasses : Constitutive Modelling and Applications
- Strengthening Mechanisms in Al-Based and Zr-Based Amorphous Nanocomposites
- Process Modelling of Equal Channel Angular Pressing for Ultrafine Grained Materials
- Molecular Dynamics Investigation on Microstructure and Void in Amorphous SiO_2
- In vivo bioluminescence imaging of cord blood derived mesenchymal stem cell transplantation into rat myocardium
- The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
- Simulation of Tunable Infra-Red Free-Electron Laser Based on Test Linac of Pohang Accelerator Laboratory
- Processing and Mechanical Properties of Fine Grained Magnesium by Equal Channel Angular Pressing
- Yield and Densification Behavior of Rapidly Solidified Magnesium Powders
- Comparison in Deformation and Fracture Behavior of Magnesium during Equal Channel Angular Pressing by Experimental and Numerical Methods
- Comparative Middle Term Results of Arthroscopic ACL Reconstruction : A Comparison of Quadrupled Semitendinosus and BPB Tendon
- Neuroprotection and Enhancement of Learning and Memory by BF-7
- A Fast and Accurate Algorithm for Computing Desired Eigenpairs of Hermitian Matrices
- 1 PPAR-Gamma Modulates Allergic Inflammation Through Upregulation of PTEN(I. Molecular Pathogenesis of Allergic Diseases)
- Erratum: Neuroprotection and Enhancement of Learning and Memory by BF-7[J. Health Sci. 51(3): 317-324 (2005)]
- Effects of Sub T_g Annealing on the Mechanical Properties of Polycarbonate/Poly (ether estre) Copolymer Blends
- Coupled Analysis of Heat Transfer and Deformation in Equal Channel Angular Pressing of Al and Steel
- Doxazosin for benign prostatic hyperplasia : An open-label, baseline-controlled study in Korean general practice
- Effects of Shear on Melt Exfoliation of Clay in Preparation of Nylon 6/Organoclay Nanocomposites
- Molecular Dynamic Simulation of Coalescence between Silver and Palladium Clusters
- Video-assisted thoracoscopic surgery : Korea University Experience
- Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, and Tissue Inhibitor of MMP (TIMP)-1 in Conjunctival Melanomas and Clinical Implications
- An Adaptive Routing Method for VoIP Gateways Based on Packet Delay Information(Network)
- Antiangiogenesis therapy using a novel angiogenesis inhibitor, anginex, following radiation causes tumor growth delay
- Mechanical Modeling of Al-Mg Alloy Open-Cell Foams
- Finite Element Analysis of the Onset of Necking and the Post-Necking Behaviour during Uniaxial Tensile Testing
- A case of testicular tunica albuginea cyst with psammoma body
- Presiction of Temperature Rise in Equal Channel Angular Pressing
- An investigation of the embryologic development of the fascia used as the basis for pancreaticoduodenal mobilization
- Encapsulation in Polysulfone/Polycarbonate/Impact Modifier Blends
- Recent Trends in Hyperthermia
- Evaluation by FEM of temperature-dependent damage behavior in quasi-isotropic carbon/epoxy laminates
- Microstructural Aspects during the Preparation of Y_3Al_5O_ by Combustion Synthesis and Temperature Field Simulation
- Predicting the Adiabatic Temperature of Transparent Y_3Al_5O_ Prepared via Combustion Synthesis under Ultra-High Gravity
- Spontaneous Rupture of a Sigmoid Colon Gastrointestinal Stromal Tumor Manifesting as Pneumoretroperitoneum with Localized Peritonitis : Report of a Case
- Surface and subsurface losses of N and P from salt-affected rice paddy fields of Saemangeum reclaimed land in South Korea
- Effects of Combined Exercise Training on Balance of Hemiplegic Stroke Patients
- Integrated nutrient management for environmental-friendly rice production in salt-affected rice paddy fields of Saemangeum reclaimed land of South Korea
- Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Changes in Postural Balance and Muscle Contraction following Muscle Fatigue
- Prediction of the Forming Limit of Porous Metals Using the Finite Element Method
- Virtual Reality Reflection Therapy Improves Motor Recovery and Motor Function in the Upper Extremities of People with Chronic Stroke
- Virtual Reality Exercise Improves Balance of Elderly Persons with Type 2 Diabetes : a Randomized Controlled Trial
- Effects of Lumbar Stabilization Exercise on Postural Sway of Patients with Adolescent Idiopathic Scoliosis during Quiet Sitting
- Effects of Rhythmic Auditory Stimulation (RAS) on Gait Ability and Symmetry after Stroke
- Virtual-Reality Balance Training with a Video-Game System Improves Dynamic Balance in Chronic Stroke Patients
- Deformation Behavior in Tubular Channel Angular Pressing (TCAP) Using Triangular and Semicircular Channels
- The Effect of Biofeedback-based Balance Training while Performing Cognitive Tasks on Temporal and Spatial Parameters and Gait Stability of the Elderly
- Losing a tongue tip from an eosinophilic ulcer of the oral mucosa
- Disruption of barrier function in dermatophytosis and pityriasis versicolor
- Comparison of the VMO/VL EMG Ratio and Onset Timing of VMO Relative to VL in Subjects with and without Patellofemoral Pain Syndrome
- Effect of Homogenization Treatment on the Microstructure and Mechanical Property Evolutions of As-Cast Al–Cu Alloy during High-Pressure Torsion
- A Single Trial of Transcutaneous Electrical Nerve Stimulation (TENS) Improves Spasticity and Balance in Patients with Chronic Stroke