Cornuside Suppresses Lipopolysaccharide-Induced Inflammatory Mediators by Inhibiting Nuclear Factor-Kappa B Activation in RAW 264.7 Macrophages
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概要
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Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside has been reported to possess immunomodulatory and anti-inflammatory activities. However, the effects and mechanism of action of cornuside in inflammation have not been fully characterized. The present study was therefore designed to examine whether cornuside suppresses inflammatory response in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Cornuside significantly inhibited the LPS-induced production of nitric oxide, prostaglandin E2, tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta. The mRNA and protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were also decreased by cornuside. Furthermore, cornuside significantly attenuated the LPS-stimulated phosphorylation and degradation of inhibitory kappa B-alpha and the subsequent translocation of the p65 subunit of nuclear factor-kappa B (NF-κB) to the nucleus. Cornuside also reduced the phosphorylations of extracellular-signal-related kinase (ERK1/2), p38, and c-Jun N-terminal kinase (JNK1/2). These results suggest that the anti-inflammatory property of cornuside is related to the downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells.
- 公益社団法人 日本薬学会の論文
著者
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Choi Yun
Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Labor
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YAN Guang
Department of Anatomy, Chonbuk National University Medical School
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LI Guang
Department of Anatomy, Yanbian University Medical School
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Choi Yun
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
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Yan Guang
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
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Jin Guang
Yanbian University Hospital, Medicine College, Yanbian University
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Li Guang
Department Of Anatomy Yanbian University Medical School
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Jin Guang
Yanbian University Hospital Medicine College Yanbian University
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Li Guang
Department Of Anatomy And Histology And Embryology Yanbian University School Of Basic Medical Scienc
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Yan Guang
Department Of Anatomy And Histology And Embryology Yanbian University School Of Basic Medical Scienc
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Li Guang
Department of Anatomy and Histology and Embryology, School of Basic Medical Sciences, Yanbian University
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Yan Guang
Department of Anatomy and Histology and Embryology, School of Basic Medical Sciences, Yanbian University
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CHOI Yun
Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk National University
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