Synthesis of 17α-Acetoxy-6-chloro-2α, 3β-dihydroxy-4,6-pregnadien-20-one, a Metabolite of Chlormadinone Acetate

スポンサーリンク

概要

• 論文の詳細を見る

• For the purpose of identifying a urinary metabolite of 17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione (I, chlormadinone acetate) in the rabbit, 17α-acetoxy-6-chloro-2α, 3β-dihydroxy-4,6-pregnadien-20-one (V), which was found to be identical with the metabolite, was synthesized from I. The starting material (I) was converted to the 2α-and 2β-acetoxy compounds (II and III) on heating with lead tetraacetate in acetic acid. When II and III were reduced with sodium borohydride in anhydrous isopropanol, two 2,3-dihydroxy compounds (V and VI) were produced. These two diols were found to be 2α, 3β-diol (V) and 2β, 3β-diol (VI), It was also found that both diols formed acetonides. 17β-acetoxy-4-androstene-2α, 3β-diol (XIII) could be also transformed into the acetonide.

• 公益社団法人日本薬学会の論文
• 1973-06-25

著者

• 神戸川 明

  Department Of Obstetrics And Gynecology School Of Medicine Teikyo University

• 神戸川 明

  Research Division, Teikoku Hormone Mfg. Co.

• 阿部 達也

  Research Division Teikoku Hormone Mfg. Co. Ltd.:(present Address)department Of Chemistry Faculty Of

関連論文

• Fluorescence Enzyme Immunoassay of 17α-Hydroxyprogesterone in Dried Blood Samples on Filter Paper and Its Application to Mass Screening for Congenital Adrenal Hyperplasia
• Mass Spectral Rearrangement : A Scope of Rearrangement of Alkylaminomethyl Group to the Ring in 1-Alkylamino-3-aryloxy-2-propanol Derivatives
• Studies on Steroid Conjugates. IX. New Synthesis of Estriol 16-and 17-Monoglucuronides
• Radioimmunoassay of 2-Hydroxyestrone Using Antisera Raised against Antigenic Complexs Obtained by Convenient Methods
• Urinary and Biliary Metabolites of 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione in the Rabbit
• Synthesis of 17α-Acetoxy-6-chloro-2α, 3β-dihydroxy-4,6-pregnadien-20-one, a Metabolite of Chlormadinone Acetate
• Identification and Anti-androgenic Activity of the Metabolites of 17α-Acetoxy-6-chloropregna-4,6-diene-3,20-dione (Chlormadinone Acetate) in the Rat, Rabbit, Dog and Man
• Isolation and Characterization of Metabolites derived from 1-tert-Butylamino-3-(2,3-dimethylphenoxy)-2-propanol (D-32), a New β-Blocker

スポンサーリンク