Urinary and Biliary Metabolites of 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione in the Rabbit

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概要

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• Ten metabolites of 17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione were isolated from urine and bile of the rabbit and their chemical structures were determined. The urinary main metabolite was 17α-acetoxy-2ξ, 3ξ-dihydroxy-5ξ-pregnan-20-one. The biliary main metabolite was 17α-acetoxy-6-chloro-2ξ, 3ξ-dihydroxy-4,6-pregnadien-20-one. The administered compound was metabolized through two courses, one was oxidation at C-2 and another was dechlorination at C-6,in the rabbit. A small amount of the metabolite oxidized at C-21 was identified from urine.

• 公益社団法人日本薬学会の論文
• 1974-12-25

著者

• 神戸川 明

  Department Of Obstetrics And Gynecology School Of Medicine Teikyo University

• 神戸川 明

  Research Division, Teikoku Hormone Mfg. Co.

• 阿部 達也

  Research Division Teikoku Hormone Mfg. Co. Ltd.:(present Address)department Of Chemistry Faculty Of

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