Isolation and Characterization of Metabolites derived from 1-tert-Butylamino-3-(2,3-dimethylphenoxy)-2-propanol (D-32), a New β-Blocker
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概要
- 論文の詳細を見る
The metabolic fate of D-32,which is a new adrenergic β-blocking agent, has been investigated with rabbit, rat and monkey. Eleven unconjugated metabolites and four conjugated metabolites were separated from urine after oral administration of D-32. The structure of these metabolites were deduced from physico-chemical data and definitely characterized by direct comparison with the authentic samples (see Chart 1). The biochemical significance of the transformation observed and the pharmacological activity of metabolites have been discussed.
- 公益社団法人日本薬学会の論文
- 1975-05-25
著者
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神戸川 明
Pharmacological Research Department Teikoku Hormone Mfg Co.
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本間 誠次郎
Research Division, Teikoku Hormone Mfg. Co.
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神戸川 明
Research Division, Teikoku Hormone Mfg. Co.
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