Cytotoxic Agents of Thujopsis dolabrata (L. fil.) SIEB. et ZUCC.
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概要
- 論文の詳細を見る
A cytotoxic agent which inhibits the division of HeLa cells at metaphase stage was isolated from Thujopsis dolabrata (L. fil.) SIEB. et ZUCC. and identified as desoxypodophyllotoxin. Three substances, desoxypodophillic acid, desoxypicropodophyllin and β-peltatin-B-methylether were isolated from the recrystallization mother liquor of desoxypodophyllotoxin after treatment with alkali. Desoxypodophyllotoxin was found to be almost exclusively contained in the leaf and bark of this tree and only in minute quantity in its wood. It was also shown to be contained in T. dolabrata var. hondae MAKINO, Juniperus rigida SIEB. et ZUCC. and J. chinensis L. by thin-layer chromatography and cytotoxicity.
- 公益社団法人日本薬学会の論文
- 1972-06-25
著者
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赤堀 昭
小太郎漢方製薬
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岡西 為人
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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赤堀 昭
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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安田 郁夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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安東 正則
塩野義製薬株式会社新薬研究所
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堀 賢二
Shionogi Research Laboratory Shionogi & Co. Ltd.
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安東 正則
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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岡西 為人
Shionogi Research Laboratory Shionogi & Co. Ltd.
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