Change of Serum Glutamic Oxaloacetic Transaminase Activities after Administration of Carbon Tetrachloride to Mice
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概要
- 論文の詳細を見る
Carbon tetrachloride (CCl_4) was orally administered to female C57BL mice (0.02,0.1,0.5,1.0 or 1.5 ml/kg). Activities of serum glutamic oxaloacetic transaminase (SGOT) were recorded at 15,24,39,48,63,72 and 87 hr after administration. SGOT levels rose more slowly but reached higher maximum levels later in mice given higher doses of CCl_4. Therefore, an inverse dose response was observed at earlier times after drug administration. This phenomenon was observed also in female C3H mice and male and adrenalectomized female C57BL mice.
- 公益社団法人日本薬学会の論文
- 1978-08-25
著者
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赤堀 昭
小太郎漢方製薬
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赤堀 昭
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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安東 正則
塩野義製薬株式会社新薬研究所
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升井 正生
Shionogi Research Laboratories Shionogi & Co. Ltd.
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安東 正則
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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