ヒマ種子中に含まれるRicinの生理活性に関する研究(第2報)Ricinの発熱性の特性について

概要

論文の詳細を見る
The pyrogenic property of purified ricin obtained from the seed of Ricinus communis was studied in comparison with bacterial pyrogen (LPS) obtained from E. Coli UKT-B. Ricin produced a durable fever in rabbits by intravenous or subcutaneous injection and caused leucopenia, but the secretion of endogenous pyrogen was not found in their serum. Response of pyrogenicity of ricin was decreased in leucopenic rabbits induced by nitrogen mustard. Tolerance to the pyrogenic effect of ricin was enhanced by its repeated subcutaneous injection but there was no evidence for cross tolerance between ricin and LPS. These results suggested that the mechanisms by which purified ricin exerts the pyrogenic effect may be different from that of LPS.
公益社団法人日本薬学会の論文
1974-08-31