ヒマ種子中に含まれるRicinの生理活性に関する研究(第4報)Concanavalin AおよびRicinの発熱活性と赤血球膜アセチルコリンエステラーゼにおよぼす影響について

概要

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The pyrogenic activity of concanavalin-A (Con.-A) and its effect on rabbit erythrocytes were studied in comparison with those of ricin. The minimum pyrogenic dose of Con.-A to the rabbit was 0.5 mg/kg, while administration of 1 mg/kg caused 2°±0.3°increase in the average body temperature. By repeated injection of Con.-A the rabbit produced an antibody to bring about pyrogenic tolerance. The cross tolerance reaction, however, was not observed among these tolerant rabbits which were repeatedly injected with Con.-A, ricin, or bacterial pyrogen. Physiological activity of Con.-A closely resembled that of ricin in point of having a lag time, duration of fever, and nonproducibility of endogenous pyrogen in feverous rabbit serum. In vitro, Con.-A and ricin (500μg/ml each) manifested 35 and 48% inhidition, individually, to the rabbit erythrocytes acetylcholinesterase, whereas no such effect was seen in the rabbit serum acetylcholinesterase. From the results of preincubation test and bloking by sugar, these inhibitory effects were distinctly attributed to blood agglutination.
公益社団法人日本薬学会の論文
1977-02-28