Degradation of β-Lactamase Inhibitor (2S, 3R, 5S)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic Acid 4,4-Dioxide (YTR-830H) in the Solid State : Structural Elucidation
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概要
- 論文の詳細を見る
(2S, 3R, 5S)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide (YTR-830H) is a new β-lactamase inhibitor. It was found that the thermal degradation of powdered or lyophilized samples of YTR-830H produced (Z)-3-methyl-4-(1H-1,2,3-triazol-1-yl)-2-butenoic acid (YTR-830H-IV), 2-amino-3-methyl-3-sulfino-4-(1H-1,2,3-triazol-1-yl)-2-butyric acid (YTR-830H-II) and its related degradation products, and formylacetic acid (YTR-830-H-III).
- 社団法人日本薬学会の論文
- 1988-11-25
著者
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吉田 健一郎
Tokushima Institute Taiho Pharmaceutical Co. Ltd.
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東 龍太郎
大鵬薬品代謝分析研
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南 慶典
Tokushima Institute, Taiho Pharmaceutical Co., Ltd.,
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松島 英司
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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南 慶典
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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東 龍太郎
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
-
吉田 健一郎
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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丸中 照義
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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南 慶典
Tokushima Institute Taiho Pharmaceutical Co. Ltd.
-
松島 英司
大鵬薬品代謝分析研
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丸中 照義
Biological Research Laboratory Taiho Pharmaceutical Co. Ltd.
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