Identification of Metabolites of 1-(Tetrahydro-2-furanyl)-5-fluorouracil (FT-207) formed in Vitro by Rat Liver Microsomes
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概要
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Four metabolites of the antitumor agent 1-(tetrahydro-2-furanyl)-5-fluorouracil, formed in vitro by rat liver microsomes, were isolated by thin-layer chromatography or high-performance liquid chromatography. On the basis of mass spectrometry, ^1H-NMR spectral analysis, and comparison with authentic samples, these metabolites were identified as 1-(trans-4-hydroxytetrahydro-2-furanyl)-5-fluorouracil, 1-(cis-4-hydroxytetrahydro-2-furanyl)-5-fluorouracil, 1-(trans-3-hydroxytetrahydro-2-furanyl)-5-fluorouracil and 1-(4,5-dehydrotetrahydro-2-furanyl)-5-fluorouracil. These metabolites were also found in the plasma and urine of rats after administration of 1-(tetrahydro-2-furanyl)-5-fluorouracil.
- 社団法人日本薬学会の論文
- 1980-06-25
著者
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丸中 照義
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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佐藤 俊幸
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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南 慶典
Research Laboratory Taiho Pharmaceutical Co. Ltd.
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藤井 節郎
Institute for Protein Research, Osaka University
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南 慶典
大鵬薬品工業 製薬セ 代謝分析研
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丸中 照義
Biological Research Laboratory Taiho Pharmaceutical Co. Ltd.
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佐藤 俊幸
大鵬薬品工業(株)代謝分析研究所
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梅野 幸彦
Biological Research Laboratory:taiho Pharmaceutical Co. Ltd.
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