Gas Chromatographic-Mass Fragmentographic Determination of 5-Fluorouracil as a Metabolite of New 5-Fluorouracil Derivatives
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概要
- 論文の詳細を見る
5-Fluoro-5'-deoxyuridine and ethyl (±)-6-n-butoxy-5-fluoro-5,6-dihydrouracil-γ-5-carboxylate are new pro-drug forms of 5-fluorouracil that have been developed as antitumor agents. A gas chromatographic-mass fragmentographic determination of the active substance 5-fluorouracil in biological materials following administration of each compound was established. The detection limit for 5-fluorouracil was 1 ng/ml of plasma and 1-5 ng/g of wet weight of visceral tissues.
- 公益社団法人日本薬学会の論文
- 1982-05-25
著者
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丸中 照義
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.,
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丸中 照義
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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丸中 照義
Biological Research Laboratory Taiho Pharmaceutical Co. Ltd.
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梅野 幸彦
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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梅野 幸彦
Biological Research Laboratory:taiho Pharmaceutical Co. Ltd.
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