Phenylalanine Derivatives Enhancing Intestinal Absorption of Insulin in Mice

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概要

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• The adjuvant effect of N-acyl-L- and D-phenylalanine derivatives on intestinal absorption of insulin was investigated in normal mice. The correlation between the chemical structural properties of the N-acyl moiety and the absorption-promoting activity was estimated from the glucose concentrations and the insulin levels in the blood of mice after oral combined administration of insulin and adjuvant. The chemical structural properties of N-acyl-phenylalanine derivatives necessary for adjuvant effect on intestinal absorption of insulin were as follows.1. An aromatic ring is present, separated by two atoms from the acyl carbonyl group.2. Either or X or Y is oxygen or X-Y is a double bond in Fig. 2.3. The N-acyl moiety has small hydrophobic substituents, such as F, Cl, or Me at R_α, R_β, R_n and has an appropriate hydropholic-hydrophobic balance of the overall molecule.The use of these agents to enhance insulin absorption offers the possibility of a new approach to oral insulin therapy.

• 社団法人日本薬学会の論文
• 1988-11-25

著者

• 熊代 泉

  Central Research Laboratories, Ajinomoto Co., Inc.

• 熊代 泉

  Central Research Laboratories Ajinomoto Co. Inc.

• 福島 紘二

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• 網野 裕右

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 川田 和広

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 戸井 浤二

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 網野 裕右

  Central Research Laboratories Ajinomoto Co. Inc.

• 戸井 浤二

  Central Research Laboratory Iatron Laboratories Inc.

• 川田 和広

  Central Research Laboratories Ajinomoto Co. Inc.

関連論文

• Synthesis of 2-Methoxyinosine and Its 5'-Phosphate
• PARTIAL SYNTHESIS OF DIHYDROTHYSANOLACTONE
• Phenylalanine Derivatives Enhancing Intestinal Absorption of Insulin in Mice
• Synthesis of 2'- and 3'-Deoxyinosines
• Synthesis of Thioinosine and Thio-AICA-riboside Analogs
• Synthesis of 9-β-D-Xylofuranosyl-6-mercaptopurine and 9-β-D-Xylofuranosylguanine 5'-Phosphate
• Synthesis of 1-N-Oxides of Adenosine and 2-Alkyladenosine and Inosine 1-N-Oxide 5'-Phosphate
• Synthesis of Thio-AICA, 6-Thioxanthine, Isoguanine Analogs, and Their Ribosides
• Synthesis of Some N^1-Methyl-2-substituted Inosines and Their 5'-Phosphates
• Synthesis of 2-Alkylthioinosine 5'-Phosphates and N^2-Methylated Guanosine 5'-Phosphates
• COLUMBIN ISOLATED FROM CALUMBAE RADIX AFFECTS THE SLEEPING TIME OF ANESTHETIZED MICE
• Synthesis of 1,5-Disubstituted Imidazoles Including an Imidazole Analogue of Prostaglandin from 4(5)-Hydroxymethylimidazole
• Noval Method for the Synthesis of 2', 3'-Unsaturated Nucleosides from 2'(3')-Acetoxy-3'(2')-halogeno Derivatives by Using Sodium Dithionite with Viologen as a Reductive Elimination Mediator
• 4 DihydrothysanolactoneおよびThysanolactoneの部分合成に関する研究
• SYNTHESIS OF THYSANOLACTONE FROM HYDROXYHOPANONE

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