Synthesis of 2-Alkylthioinosine 5'-Phosphates and N^2-Methylated Guanosine 5'-Phosphates
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概要
- 論文の詳細を見る
2-Alkylthioinosine 5'-phosphates and N^2-methylated guanosine 5'-phosphates (the minor constituents of transfer RNA) were synthesized via 2', 3'-O-isopropylidene-2-mercaptoinosine (I) from 5-amino-1-β-D-ribofuranosyl-4-imidazolecarboxamide (AICA-riboside). The relationship between their chemical structures and flavoring activity was investigated, and 2-methylthioinosine 5'-phosphate (VII) was found to have an extremely strong flavoring activity.
- 公益社団法人日本薬学会の論文
- 1968-02-25
著者
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山崎 晤弘
Central Research Laboratories, Ajinomoto Co., Inc.
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熊代 泉
Central Research Laboratories, Ajinomoto Co., Inc.
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熊代 泉
Central Research Laboratories Ajinomoto Co. Inc.
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山崎 晤弘
Central Research Laboratories Ajinomoto Co. Inc.
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竹西 忠男
Central Research Laboratories, Ajinomoto Co., Inc.
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竹西 忠男
Central Research Laboratories Ajinomoto Co. Inc.
関連論文
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- Phenylalanine Derivatives Enhancing Intestinal Absorption of Insulin in Mice
- Synthesis of 5-Amino-1-(3'-deoxy-β-D-ribofuranosyl)-4-imidazolethiocarboxamide
- Synthesis of 2'- and 3'-Deoxyinosines
- Synthesis of Thioinosine and Thio-AICA-riboside Analogs
- Synthesis of 9-β-D-Xylofuranosyl-6-mercaptopurine and 9-β-D-Xylofuranosylguanine 5'-Phosphate
- Synthesis of 9-(4'-Hydroxybutyl)-2-amino-6-hydroxypurine 4'-Phosphate
- Synthesis of 1-N-Oxides of Adenosine and 2-Alkyladenosine and Inosine 1-N-Oxide 5'-Phosphate
- Synthesis of Thio-AICA, 6-Thioxanthine, Isoguanine Analogs, and Their Ribosides
- Synthesis of Some N^1-Methyl-2-substituted Inosines and Their 5'-Phosphates
- Synthesis of 2-Alkylthioinosine 5'-Phosphates and N^2-Methylated Guanosine 5'-Phosphates
- Studies on Coenzyme Analogs. XIII. Oxidation of Methylmercaptopurine and its Nucleoside by means of N-Chloro-and N-bromosuccinimide.
- Potential Antimetabolites. IV. Synthesis of 2,6-Bis-alkylthiopurine Ribosides and their Selective Substitution by Nucleophilic Reagents.
- トランスグリコシレーション法によるプリンヌクレオシド類の合成