Synthesis of 1,5-Disubstituted Imidazoles Including an Imidazole Analogue of Prostaglandin from 4(5)-Hydroxymethylimidazole

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概要

• 論文の詳細を見る

• 1-(6-Carboxyhexyl)-5-[(E)-3-hydroxy-1-octenyl]midazole, an imidazole analogue of prostaglandin, was synthesized from 4(5)-hydroxymethylimidazole hydrochloride. The key step involves regioselective alkylation of 4(5)-tertbutyldimethylsilyloxymethylimidazole to give predominantly 1,5-disubstituted imidazole.

• 公益社団法人日本薬学会の論文
• 1989-06-25

著者

• 網野 裕右

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 江口 新比古

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 網野 裕右

  Central Research Laboratories Ajinomoto Co. Inc.

• 江口 新比古

  Central Research Laboratories Ajinomoto Co. Inc.

• 江藤 弘純

  Central Research Laboratories Ajinomoto Co., Inc.

• 江藤 弘純

  Central Research Laboratories Ajinomoto Co. Inc.

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