Unexpected Chain-Terminating Side Reaction Caused by Histidine and Acetic Anhydride in Solid-Phase Peptide Synthesis

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概要

• 論文の詳細を見る

• Capping is a useful technique to facilitate purification of a crude deprotected peptide in solid-phase peptide synthesis. However, we observed a serious side reaction caused by the Ac_2O capping procedure, when it was applied to a synthesis of a peptide containing His. The mechanism of the side reaction was studied.

• 公益社団法人日本薬学会の論文
• 1989-02-25

著者

• 石黒 恒男

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 江口 新比古

  Central Research Laboratories, Ajinomoto Co., Inc.,

• 江口 新比古

  Central Research Laboratories Ajinomoto Co. Inc.

• 石黒 恒男

  Central Research Laboratories Ajinomoto Co. Inc.

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