抗炎症剤の赤血球膜安定化作用(第2報) : 紫外線照射によるイヌ赤血球の溶血現象とLipid Peroxidation, 抽出脂質のLipid Peroxide生成および紫外線照射脂質による溶血におよぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Further studies were made on the relation between hemolysis and lipid peroxidation, and on the effect of anti-inflammatory drugs on each phenomenon. ultraviolet-irradiation caused a marked hemolysis in canine erythrocyte (RBC), accompanied by the formation of lipid peroxides. Lipid peroxidation was also observed in the ultraviolet-irradiated suspension of the lipid extracts from RBC membrane, which preparation produced in vivo a significant enhancement of the capillary permeability of a dye when injected intradermally in the dorsal skin of guinea pigs, and in vitro hemolysis when added to and incubated with RBC. The hemolysis induced by the irradiated lipid, as well as the hemolysis and lipid peroxide formation following UV, progressed as a function of time. A great inhibition of both phenomena, which occurred simultaneously in RBC following UV, was produced when mefenamic and salicylic acids, oxyphenbutazone, aminopyrine, chloroquine, or betamethasone was present in a final concentration of 7.5×10^<-4>M. Under the same condition, flufenamic acid inhibited considerably the lipid peroxidation and to a much lesser extent hemolysis, while in contrast aspirin protected RBC more from hemolysis than from lipid peroxide formation. Phenylbutazone and prednisolone had no inhibitory effect on both instances. Although the TBA color reaction was not modified significantly with anti-inflammatory drugs whether ferric ion was present or not, the rise of TBA value in the irradiated lipid suspension decreased significantly with phenylbutazone, aminopyrine, flufenamic acid, and chloroquine, but increased considerably with mefenamic and salicylic acids, and betamethasone in this descending order. The hemolysis induced by the irradiated lipid suspension was suppressed effectively when oxyphenbutazone, aminopyrine, chloroquine, or mefenamic acid was added finally at 3.25×10^<-4>M. Inhibition was also produced mildly with betamethasone, flufenamic acid, and salicylic acids. Aspirin, phenylbutazone, and prednisolone were inactive against the irradiated lipid induced hemolysis at the concentration used here. It was assumed that anti-inflammatory drugs would probably inhibit RBC hemolysis by stabilizing lipoprotein of the membrane, or by absorbing and destroying free radicals or peroxides.
- 公益社団法人日本薬学会の論文
- 1970-11-25
著者
関連論文
- Thiamine disulfide誘導体の研究 : (II)Thiamine disulfide誘導体の生物学的効力
- Thiamine disulfide誘導体の研究 : (I)Thiamine disulfide誘導体の合成
- アンスラニル酸関連化合物の抗炎症作用(第2報) : アクリジン・モノおよびジカルボン酸, オキソアクリダン・モノカルボン酸誘導体について
- Hydrocortisone 17-butyrate 21-propionateの 特殊毒性に関する研究
- 体温低下の水泳行動に及ぼす影響
- ヒドロコルチゾン17,21-ジエステル類の合成と抗炎症作用
- 抗炎症薬の赤血球膜安定化作用(第3報)非Steroid系抗炎症薬とα-Tocopherolの比較
- 抗炎症剤の赤血球膜安定化作用(第2報) : 紫外線照射によるイヌ赤血球の溶血現象とLipid Peroxidation, 抽出脂質のLipid Peroxide生成および紫外線照射脂質による溶血におよぼす影響
- 抗炎症剤の赤血球膜安定化作用(第1報) : H_2O_2によるイヌ赤血球の溶血現象とLipid Peroxidationにおよぼす影響
- 海亀油成分の研究(第5報) : Sterolの組成について
- Thiamine disulfide誘導体の研究 : (VII)Isobutyroylthiamine disulfide-^Sの生体内分布とその排泄
- o-Isobutyrylthiamine Disulfideの実験的炎症疼痛にたいする鎮痛作用
- アンスラニル酸関連化合物の抗炎症作用(第1報) : N-フェニルアンスラニル酸誘導体について
- Hydrocortisone 17-butyrate 21-propionateの薬理学的研究
- 抗炎症薬の研究(第1報) モルモット Arachidonic acid 皮膚発赤に対する抗炎症薬の作用
- D-Penicillamine の研究(第5報) D-Penicillamine および抗リウマチ薬のラットAdjuvant 関節炎におよぼす影響
- D-Penicillamine の研究(第4報) 抗体産生系に対する作用
- D-Penicillamineの研究(第2報) ラットにおけるD-Penicillamineの抗VitaminB6作用と金属排泄作用について