抗炎症薬の赤血球膜安定化作用(第3報)非Steroid系抗炎症薬とα-Tocopherolの比較

概要

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Non-steroidal anti-inflammatory drugs and α-tocopherol were tested in vitro for inhibition against hemolysis and lipid peroxidation induced by H_2O_2 in erythrocytes from healthy mongrel dogs. In concentration over the range of 10^<-6> to 4.5×10^<-4>M, anti-inflammatory drugs inhibited both hemolysis and lipid peroxidation, while α-tocopherol had no effect. Against peroxidation of free unsaturated fatty acids caused by various means (H_2O_2,UV irradiation, ascorbic acid+Fe^<+2>, and hemoglobin), antioxidants including α-tocopherol showed a marked inhibition, whereas almost all anti-inflammatory drugs had no effect. H_2O_2 was not destroyed directly by both antioxidants and anti-inflammatory drugs. Diphenyl-p-picrylhydrazyl, a model compound of free radical, was reduced powerfully with antioxidants but not with anti-inflammatory drugs.
公益社団法人日本薬学会の論文
1973-06-25