Cimicifuga属植物の成分研究(第6報) : 25-O-Acetylcimigenosideと25-O-Methylcimigenosideの構造

概要

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25-O-Acetylcimigenoside (I), mp 234-235°, C_<37>H_<58>O_<10>, is obtained from the subterranean portion of Cimicifuga acerina and 25-O-methylcimigenoside (IV), mp 268-270°, C_<36>H_<58>O_9,from that of C. acerina and C. japonica. Enzymic hydrolysis of I gave 25-O-acetylcimigenol (II) while its acid hydrolysis gave cimigenol (VII) and xylose. Acetylation of I, followed by chromium trioxide oxidation and acid hydrolysis gave cimigen-15-one (III). From these evidences and from the measurement of NMR spectrum and ORD, formula I was given to 25-O-acetylcimigenoside. IV formed 25-O-methylcimigenol (V), either by refluxing with 50% acetic acid or by enzymic hydrolysis. Acetylation of IV followed by chromium trioxide oxidation and consecutive alkaline and acid hydrolyses gave 25-O-methylcimigen-15-one (VI). Formula IV was given to 25-O-methylcimigenoside from the above experimental results and measurement of NMR spectrum and ORD.
社団法人日本薬学会の論文
1970-01-25