副腎皮質ホルモン含有軟膏の研究(第6報) : Hydrocortisone-4-^<14>Cの経皮吸収その2 Excised Skinを使用したin Vitroの経皮吸収について

概要

論文の詳細を見る
Effect of nonionic surface active agent (lauric diethanolamide; HS-12-P) and the effect of the concentration of hydrocortisone acetate-4-^<14>C on the release of hydrocortisone from liquid vehicle to the human excised skin are described. The relationship between the release of hydrocortisone acetate and concentration of HS-12-P to the excised human skin was observed as shown in Fig.1. The results showed that the rate of the release of hydrocortisone acetate was increased with increasing concentration of HS-12-P up to 7% but, above that concentration, the rate was reduced. This reduction depends on the entrapment of hydrocortisone acetate in micelles. The rate of release of hydrocortisone acetate increased proportionally with increasing concentration of hydrocortisone acetate when using a liquid vehicles, i.e., liquid paraffin (Fig. 5), propylene glycol (30%) -H_2O (70%) (Fig. 3), and HS-12-P (10%) -H_2O (90%) (Fig. 4). It was suggested that the proportional relation between the concentration and rate of release of hydrocortisone acetate was not related to the solubilities of hydrocortisone acetate in each liquid vehicles.
公益社団法人日本薬学会の論文
1969-09-25