台湾産クスノキ科植物アルカロイド研究(第12報) : コニシグスCryptocarya Konishii HAYATAおよびウスバタブMachilus acuminatissima(HAY.)KANEHIRAのアルカロイド

概要

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A study was made on the colorless needle crystals (named "crykonisine"), m.p. 235〜236°(decomp.) of the alkaloids isolated from Cryptocary Konishii HAYATA (Japanese name "Konishi-gusu"). Crykonisine shows : [α]^<23>_D±0°(EtOH), C_<18>H_<17>O_3N, two OCH_3 groups, one phenolic hydroxyl group, and real benzylisoquinoline type bases of UV absorption spectrum (Fig.2), tetrahydro derivative treated with zinc powder in HCl shows [α]^<23>_D±0°(CHCl_3), colorless neddles, m.p. 139〜140°, which is identical with dl-N-norarmepevine (II). Therefore, the structure of crykonisine has been determined as 1-(p-hydroxybenzyl)-6,7-dimethoxyisoquinoline (I). On the other hand, an investigation was made on the alkaloids from the rootwood and root bark of Machilus acuminatissima (HAY.) KANEHIRA (Japanese name "Usuba-tabu", Chinese name "Chien-yeh-nan") and L-(-)-N-norarmepavine, dl-N-norarmepevine, dl-coclaurine and crykonisine (I) from rootwood, and L-(-)-N-norarmepavine and dl-coclaurine from root bark roots were isolated and have been confirmed. (Table I).
公益社団法人日本薬学会の論文
1967-10-25